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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

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Bone Maturation in 1788 Children and Adolescents with Diabetes Mellitus Type 1

Axel Dost1 / Tilman Rohrer2 / Jörg Fussenegger3 / Christian Vogel4 / Bernd Schenk5 / Martin Wabitsch6 / Beate Karges7 / Claudia Vilser1 / Reinhard W. Holl8

1Department of Pediatrics, University of Jena, Germany

2Department of Pediatrics, University of Homburg, Germany

3Children's Hospitals Dornbirn, Germany

4Children's Hospitals Chemnitz, Germany

5Children's Hospitals Helios Klinikum Schwerin, Germany

6Department of Pediatrics, University of Ulm, Germany

7RWTH Aachen University, Germany

8University of Ulm, Germany

Corresponding author: Dr. Axel Dost, MD,

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 23, Issue 9, Pages 891–898, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem.2010.144, December 2010

Publication History

Published Online:


Diabetes mellitus type 1 might interfere with pubertal development. Particularly, longterm metabolic control and intensity of insulin treatment have been reported to contribute to a delay in pubertal onset. Data on somatic development in diabetic children are conflicting; therefore we studied bone age in 1788 children from Germany and Austria with type 1 diabetes. Bone age was retarded by -0.27 ± 1.1 years in the whole group, but particularly in the adolescents at the end of puberty (>16 years; -0.76±1.29y). Bone age delay was more pronounced in boys, and in children with longterm median HbA1c levels of 7.5 – 9.0%. No associations were found with current HbA1c levels or the intensity of insulin treatment. Bone age determinations in diabetic children should only be performed when clinical signs of impaired somatic development are present. In addition, the potential influence of diabetes on bone development needs to be considered in the interpretation of carpograms.

KEY WORDS: auxiology; bone age determination; diabetes mellitus

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