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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

12 Issues per year

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Insulin Resistance and the Metabolic Syndrome in Obese Children Referred to an Obesity Center

J. Rotteveel1 / A. Felius1 / M. M. van Weissenbruch1 / H. A. Delemarre–Van de Waal1

1Department of Pediatrics, VU University Medical Center, Amsterdam, and Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands

Corresponding author: J. Rotteveel,

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 23, Issue 9, Pages 943–951, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem.2010.151, December 2010

Publication History

Published Online:


Objective: The aim of this study was to describe insulin resistance and the metabolic syndrome in obese children and adolescents.

Subjects: The cohort consisted of 518 patients, 250 boys, 268 girls, age ± sd: 11.8 ± 3.2 years, BMIsds ± sd: 2.94 ± 0.5. A standard OGTT was performed.

Results: Impaired glucose tolerance was found in 9.4% of the boys and 5.5% of the girls. Impaired fasting glucose was found in 12.4% of the boys and 11.6% of the girls. The metabolic syndrome was present in 13.9% of children of 10 years or older. The proportion in which the metabolic syndrome was diagnosed was essentially not altered when pubertal groups were used instead of age groups.

Conclusion: Both impaired fasting glucose and impaired glucose tolerance as well as the metabolic syndrome are highly prevalent among obese children and adolescents.

KEY WORDS: obesity; metabolic syndrome; insulin resistance

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