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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

12 Issues per year


IMPACT FACTOR 2013: 0.711

SCImago Journal Rank (SJR): 0.334
Source Normalized Impact per Paper (SNIP): 0.423

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Vitamin D deficiency and insulin resistance in obese African- American adolescents

Gail Nunlee-Bland1 / Kanwal Gambhir1 / Cynthia Abrams2 / Mustapha Abdul1 / Marjan Vahedi1 / Wolali Odonkor1

1Division of Endocrinology, Howard University, Washington, DC, USA

2Department of Biochemistry and Molecular Biology, Howard University, Washington, DC, USA

Corresponding author: Gail Nunlee-Bland, Howard University Hospital, 2041 Georgia Avenue NW, Washington, DC 20060, USA Phone: +202-865-3350, Fax: +202-865-3495

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 24, Issue 1-2, Pages 29–33, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem.2011.107, March 2011

Publication History

Published Online:
2011-03-16

Abstract

Objective: The study aim determined if low 25-hydroxy vitamin D levels correlated with low levels of adiponectin and insulin resistance in African American adolescents with body mass index ≥85th%.

Patients and methods: Fasting blood levels of adiponectin, 25-hydroxy vitamin D, insulin, glucose, lipid, leptin and glycosylated hemoglobin were measured in a total of 34 (19 study and 15 control) African American adolescents between the ages of 10 and 20 years. Nutritional vitamin D intake and body composition measurements were assessed. Insulin resistance was calculated using the homeostasis model assessment.

Results: Adiponectin, fasting insulin, glucose, leptin, triglycerides, HDL, and 25-hydroxy vitamin D levels all reached statistical significance in the group with body mass index ≥85th percentile when compared to the control population. There was no difference in vitamin D intake between the two groups.

Conclusions: Low vitamin D levels correlated with low adiponectin levels and obesity and insulin resistance.

Keywords: African-American; adiponectin; adolescents; insulin resistance; obesity; vitamin D

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