Vitamin D status and insulin requirements in children and adolescent with type 1 diabetes : Journal of Pediatric Endocrinology and Metabolism uses cookies, tags, and tracking settings to store information that help give you the very best browsing experience.
To understand more about cookies, tags, and tracking, see our Privacy Statement
I accept all cookies for the De Gruyter Online site

Jump to ContentJump to Main Navigation

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Roth, Christian / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

IMPACT FACTOR increased in 2014: 0.995

SCImago Journal Rank (SJR) 2014: 0.378
Source Normalized Impact per Paper (SNIP) 2014: 0.454
Impact per Publication (IPP) 2014: 0.880



30,00 € / $42.00 / £23.00

Get Access to Full Text

Vitamin D status and insulin requirements in children and adolescent with type 1 diabetes

Ozgul Tunc1 / 2 / Murat Kızılgün1 / Zehra Aycan2

1Ankara Dışkapı Children’s Health and Disease Training and Research Hospital, Ankara, Turkey

2Dr. Sami Ulus Obstetrics and Gynecology, Children’s Health and Disease Training and Research Hospital, Ankara, Turkey

Corresponding author: Semra Cetinkaya, MD, Kozluevler, 3251 Cadde, 2/28, Yasamkent, Ankara TR-06810, Turkey Phone: +90 505 3884403, Fax: +90 312 3170353

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 24, Issue 11-12, Pages 1037–1041, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/JPEM.2011.213, November 2011

Publication History

Published Online:


Background: Vitamin D and its active form are potent immuno­modulators and are known to play an important role in the glucose/insulin metabolism. Studies on type 2 diabetes mellitus (T2DM) have shown that vitamin D increases insulin efficacy; however, there are no studies that define a similar relationship in type 1 diabetes mellitus (T1DM). The aim of this study was to investigate the relation between serum vitamin D levels and the insulin requirement used in children with T1DM.

Subjects and methods: A total of 100 patients with T1DM aged 4.7–19.9 years were included in the study. Serum calcium, phosphorus, alkaline phosphatase, parathyroid hormone, 25-hydroxyvitamin D (25OHD), and 1,25-dihydroxyvitamin D were measured. A serum 25OHD level of <10 ng/mL was accepted as vitamin D deficiency, whereas <20 ng/mL was accepted as vitamin D insufficiency.

Results: We found vitamin D deficiency in 28% and vitamin D insufficiency in 43% of our patients, whereas 29% had normal serum 25OHD levels. The insulin requirement of patients with a serum 25OHD level below 10 ng/mL were significantly higher than those of patients with a serum 25OHD level above 10 ng/mL (p=0.012). This result did not change in those with diabetes duration of over 1 year. There was weak correlation between the daily insulin requirements and serum vitamin D levels (r=–0.212, p=0.032).

Conclusion: We found a significantly higher insulin requirement in T1DM children with decreased serum 25OHD levels and decreased insulin sensitivity. We recommend checking the level of serum 25OHD in children with diabetes and starting treatment if it is deficient/inadequate.

Keywords: insulin sensitivity; type 1 diabetes; vitamin D

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Craig Sheedy, Meng Xu, Ben Saville, and Jill Simmons
Journal of Diabetes Mellitus, 2014, Volume 04, Number 04, Page 324
Nithya Setty-Shah, Louise Maranda, and Benjamin Udoka Nwosu
Gastroenterology Research and Practice, 2014, Volume 2014, Page 1

Comments (0)

Please log in or register to comment.