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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

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Primary ovarian dysfunction after hematopoietic stem cell transplantation during childhood: busulfan-based conditioning is a major concern

Won-Kyoung Cho1 / Jae-Wook Lee1 / Nak Gyun Chung1 / Min Ho Jung1 / Bin Cho1 / 1 / Hack Ki Kim1

1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, Seoul, South Korea

Corresponding author: Byung-Kyu Suh, MD, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul St. Mary’s Hospital, 505, Banpo-Dong, Seocho-Gu, Seoul 137-040, South Korea Phone: +82 2-2258-6185, Fax: +82 2-532-6185

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 24, Issue 11-12, Pages 1031–1035, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/JPEM.2011.339, November 2011

Publication History

Published Online:


We evaluated the incidence of patient/treatment factors associated with primary ovarian failure (POF) after hematopoietic stem cell transplantation (HSCT) during childhood. Fifty girls over 12 years of age (15.0±2.2) who were referred to the pediatric endocrinology clinic between March 2002 and March 2010 after HSCT at the Catholic HSCT center were enrolled in the study. In total, 36 (72%) out of 50 patients developed POF. Twenty-three patients were diagnosed and treated as chronic graft-versus-host disease. As preparative regimens for HSCT, 23 patients received total body irradiation (TBI)-based regimen, 19 received busulfan (BU)-based regimen, 4 received both BU- and TBI-based, and 4 received reduced intensity conditioning regimen. In a univariate logistic regression analysis, the BU-based regimen (p=0.028) showed a strong relationship with POF. The incidence of POF according to the route of BU administration, between orally and intravenously, were not different (p=0.435). These results emphasize the importance of monitoring these patients at regular intervals and the need to develop complementary HSCT protocols for preventing POF in children.

Keywords: busulfan; hematopoietic stem cell transplantation; primary ovarian insufficiency

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