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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

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Benign transient hyperphosphatasemia in infants and children: a prospective cohort

1, 2 / Alexandra Laskowski3 / Frank P. Barrows2, 4

1Pediatric Gastroenterology and Nutrition, The Children’s Hospital at Monmouth Medical Center, Long Branch, NJ, USA

2Drexel University School of Medicine, Philadelphia, PA, USA

3Department of Pediatrics, The Children’s Hospital at Monmouth Medical Center, Long Branch, NJ, USA

4Pediatric Endocrinology and Diabetes, The Children’s Hospital at Monmouth Medical Center, Long Branch, NJ, USA

Corresponding author: Jonathan E. Teitelbaum, MD, Department of Pediatrics, The Children’s Hospital at Monmouth Medical Center, 300 Second Ave, Long Branch, NJ 07750, USA Phone: +1-732-923-6080, Fax: +1-732-923-6083

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 24, Issue 5-6, Pages 351–353, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem.2011.025, May 2011

Publication History

Published Online:
2011-05-31

Abstract

A total of 20 children with benign transient hyperphosphatasemia were prospectively evaluated with no additional investigations recommended except repeat serologic evaluation in 2–3 months. The average age of our patients was 2.5 years (range 1 year 2 months–5 years 10 months). The serum levels of alkaline phosphatase averaged 2383 IU/L (range 1013–5700 IU/L). Levels returned to normal within several months. This condition should be recognized by the clinician in order not to put patients through lengthy, expensive and unnecessary investigations.

Keywords: alkaline phosphatase; benign transient hyperphosphatasemia; cohort study

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