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Journal of Pediatric Endocrinology and Metabolism

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The relation between 25-hydroxyvitamin D with peak bone mineral density and body composition in healthy young adults

1 / Eric P. Krenning2 / Sabine M.P.F. de Muinck Keizer-Schrama3

1Division of Endocrinology, Department of Pediatrics, University Medical Center Groningen, Beatrix Children’s Hospital, Groningen, The Netherlands

2Department of Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands

3Division of Endocrinology, Department of Pediatrics, Erasmus MC– Sophia Children’s Hospital, Rotterdam, The Netherlands

Corresponding author: Annemieke M. Boot, UMCG–Beatrix Children’s Hospital, P.O. Box 30001, 9700 RB Groningen, The Netherlands Phone: +31 50 3611079, Fax: +31 50 3614235

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 24, Issue 5-6, Pages 355–360, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem.2011.052, May 2011

Publication History

Published Online:
2011-05-31

Abstract

Objective: The associations between peak bone mineral density (BMD) and body composition with 25 hydroxyvitamin D (25OHD) levels in healthy young adults were evaluated.

Methods: The number of participants was 464; 347 women and 117 men. The mean age was 24.3 years (range 17–31 years). BMD of the lumbar spine, total body and femoral neck (FN) and body composition were measured by dual energy X-ray absorptiometry. Volumetric BMD, bone mineral apparent density (BMAD), of the lumbar spine and FN was calculated.

Results: In females, 25OHD level was positively associated with FN BMD and BMAD (both p<0.01) and negatively with percentage body fat (p<0.001). In males, 25OHD levels had a positive association with total body BMD and lean body mass (p=0.03 and p=0.01).

Conclusions: 25OHD level is a determinant of peak BMD in both sexes. Vitamin D status was associated with body fat in females and with lean body mass in males.

Keywords: bone mineral density; fat mass; insulin-like growth factor-1; lean body mass; vitamin D

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