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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

12 Issues per year


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Cord blood adiponectin and infant growth at one year

Shali Mazaki-Tovi1 / Hannah Kanety2, 3 / Clara Pariente3 / Rina Hemi3 / Jacob Kuint2, 4 / Yoav Yinon1 / Eyal Schiff1, 2 / 1, 2

1Department of Obstetrics and Gynecology, The Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Tel-Hashomer, Israel

2Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

3Institute of Endocrinology, The Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Tel-Hashomer, Israel

4Department of Neonatology, The Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Tel-Hashomer, Israel

Corresponding author: Eyal Sivan, MD, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, 52621, Israel Phone: +972-3-5302169, Fax: +972-3-5302922

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 24, Issue 7-8, Pages 411–418, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem.2011.181, June 2011

Publication History

Published Online:
2011-06-21

Abstract

Objective: The aim of this study was to determine the association between cord blood adiponectin and leptin and early infant growth at one year in small for gestational age (SGA) and appropriate for gestational age (AGA) infants.

Study design: In this prospective study adiponectin and leptin concentrations were determined in cord blood of (i) AGA newborns (n=44) and (ii) SGA newborns (n=24). At one year of age, height and weight were measured. Linear regression analysis was used to determine which factors were associated with anthropometric measurements at the age of one year.

Results: (i) SGA neonates had a significantly lower median cord blood adiponectin and leptin than AGA neonates; (ii) among SGA neonates, cord blood adiponectin concentrations were negatively correlated with body weight at one year, weight gain after one year and with BMI at one year; and (iii) among AGA neonates cord blood adiponectin concentrations were negatively correlated with body weight at one year, weight gain after one year and with BMI at one year.

Conclusion: The disparity in cord blood adiponectin and leptin concentrations between SGA and AGA neonates suggests a role for adipokines in fetal growth.

Keywords: adipokines; appropriate for gestational age (AGA); fetus; neonatal growth; pregnancy; small for gestational age (SGA)

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