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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

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Comparative analysis of clinical, biochemical and genetic aspects associated with bone mineral density in small for gestational age children

Liliana Silvano1, a / Mirta Miras1, a / Adriana Pérez2 / Gabriela Picotto2 / Gabriela Díaz de Barboza2 / Liliana Muñoz1 / Silvia Martin1 / Gabriela Sobrero1 / Pedro Armelini 3 / Verónica Mericq4 / 2 /

1Servicio de Endocrinología, Hospital de Niños de la Santísima Trinidad, Córdoba, Argentina

2Laboratorio “Dr. Cañas”, Cátedra de Bioqu í mica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina

3Cátedra de Pediatría, Facultad de Medicina, Universidad Católica de Córdoba, Córdoba, Argentina

4Instituto de Investigaciones Materno Infantil, Universidad de Chile, Santiago de Chile, Chile

aThese authors have contributed equally to this article.

bThe collaborating group included: Esteban Pretel E, Susana De Grandis S, Juan Talamoni, Eliana Elias, Mariana Onassis, Laura Castro L, Carolina Alvarez Troncoso, Nestor Soria, Andrés Gomila.

Corresponding author: Professor Dr. Nori Tolosa de Talamoni, Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, (5000) Córdoba, Argentina Phone: +54 351 333024 EXT 121, Fax: +54 31 4333072

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 24, Issue 7-8, Pages 511–517, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem.2011.196, June 2011

Publication History

Published Online:
2011-06-29

Abstract

Clinical, biochemical and genetic analysis related to bone mineral density (BMD) were carried out in children born small for gestational age (SGA) that failed to achieve postnatal catch-up growth (CUG), SGA children that completed CUG and adequate for gestational age (AGA) children. Serum IGF-I, IGF-II, IGF binding protein-3 and acid-labile subunit were lower in the SGA–CUG children as compared with the other groups. Frequencies of polymorphic variants of vitamin D receptor, estrogen receptor and collagen genes were similar among groups. The genotype 194–192 of the IGF-I gene was higher in the SGA–CUG and 196–192 was higher in the SGA+CUG group. In the SGA–CUG group, the genotype SS of the COLIA1 gene was associated with lower BMD. Therefore, IGF system and COLIA1 polymorphism distinguish prepubertal SGA–CUG children from the SGA+CUG children of the same age. Furthermore, COLIA1 polymorphism could be useful to predict osteopenia in SGA–CUG children.

Keywords: bone mineral density; gene polymorphism; IGF system; small for gestational age

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