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Publication Date:
August 2011
ISSN:
2191-0251
DOI:
10.1515/jpem.2011.238

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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Zadik, Zvi

Editorial Board Member: Cassorla, Fernando / Cutfield, Wayne / de Muinck Keizer-Schrama, Sabine M.P.F. / Fideleff, Hugo L. / LaFranch, Stephen H. / Lanes M. D., Roberto / Levitsky, Lynne / Lippe, Barbara / Pfäffle, Roland / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Kiess, Wieland

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Pulmonary hypertension and reopening of the ductus arteriosus in an infant treated with diazoxide

1 / Sevim Unal2 / I. Ilker Çetin3 / Ihsan Esen1 / Aslıhan Araslı4

1Department of Pediatric Endocrinology, Ankara Child Diseases, Hematology and Oncology Training Hospital, Ankara, Turkey

2Department of Neonatology, Ankara Child Diseases, Hematology and Oncology Training Hospital, Ankara, Turkey

3Department of Pediatric Cardiology, Ankara Child Diseases, Hematology and Oncology Training Hospital, Ankara, Turkey

4Department of Pediatrics, Ankara Child Diseases, Hematology and Oncology Training Hospital, Ankara, Turkey

Corresponding author: Fatma Demirel, Department of Pediatric Endocrinology, Ankara Child Diseases, Hematology and Oncology Training Hospital, Ankara, Turkey Phone: +90 312 596 9666, Fax: +90 312 347 23 30

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 24, Issue 7-8, Pages 603–605, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem.2011.238, August 2011

Publication History:
Received:
2011-04-02
Accepted:
2011-04-06

Abstract

Diazoxide is the main therapeutic agent for persistent hyperinsulinemic hypoglycemia. Generally, it is tolerated well, but rarely it can cause severe life-threatening complications. We report a neonate who was treated with diazoxide for hyperinsulinemic hypoglycemia. On the 6th day of the treatment we observed sepsis-mimicking symptoms, mild pulmonary hypertension, and re-opening of the ductus arteriosus. All these findings resolved dramatically shortly after discontinuation of treatment. To our knowledge, this is the first reported case of re-opening of the ductus arteriosus due to diazoxide toxicity.

Keywords: diazoxide; ductus arteriosus; pulmonary hypertension; toxic effect

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