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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

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Retinol-binding protein 4 correlates with triglycerides but not insulin resistance in prepubertal children with and without premature adrenarche

1 / Adrienne T. Gerken1 / Eun-Ju Lee1 / William E. Blaner2 / Stefanie Deeds1 / Dympna Gallagher2 / Dikoma C. Shungu3 / Xiangling Mao3 / Abeer Hassoun1 / Donald J. Mc Mahon2 / Sharon E. Oberfield1

1Department of Pediatrics, Columbia University Medical Center, New York, NY, USA

2Department of Medicine, Columbia University Medical Center, New York, NY, USA

3Department of Radiology, Weill Cornell Medical College, New York, NY, USA

Corresponding author: Aviva B. Sopher, MD, 622 W 168th St, PH 5E-522, New York, NY 10032, USA Phone: +1 212 3056559, Fax: +1 212 3054778

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 24, Issue 9-10, Pages 683–687, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/JPEM.2011.322, September 2011

Publication History

Received:
2011-06-23
Accepted:
2011-08-16
Published Online:
2011-09-20

Abstract

Background: Retinol-binding protein 4 (RBP4) has been proposed as an early marker for insulin resistance (IR), but no prior studies have addressed RBP4 in an exclusively prepubertal population. Children with premature adrenarche (PA) are at increased risk for IR and metabolic syndrome (MeS); thus finding an appropriate early marker for IR in this population would allow for early intervention and prevention of morbidity related to IR and MeS.

Objective: To determine whether prepubertal children with PA have higher levels of RBP4 than controls and whether RBP4 correlates with comorbidities of metabolic disease in prepubertal children.

Subjects: This study comprised 49 prepubertal children (24 with PA and 25 control subjects), 20 boys and 29 girls, who were between the ages of 5 and 9 years.

Methods: This was a cross-sectional, case-control study conducted in a subspecialty ambulatory clinic based in a quaternary care center. RBP4 levels, hormonal values, lipids, and response to an oral glucose tolerance test were evaluated in children with PA and controls, and body composition measures were obtained in a subset of patients (n=18).

Results: RBP4 correlated with triglycerides (r=0.57, p<0.0001) but did not correlate with IR in a body mass index z-score-adjusted Pearson correlation analysis. There was no difference in RBP4 levels between the PA and control groups.

Conclusions: These findings suggest that RBP4 may be an early marker of dyslipidemia, which may herald future onset of hepatic IR, polycystic ovary syndrome, and MeS.

Keywords: insulin resistance; premature adrenarche; premature pubarche; retinol-binding protein 4

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[1]
Aviva B. Sopher, Adrienne T. Gerken, William S. Blaner, Jeremy M. Root, Donald J. McMahon, and Sharon E. Oberfield
Fertility and Sterility, 2012, Volume 97, Number 4, Page 1009

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