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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

12 Issues per year


IMPACT FACTOR 2013: 0.711

SCImago Journal Rank (SJR): 0.334
Source Normalized Impact per Paper (SNIP): 0.423

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Ultrasonographic description of brain cortex and cingulate sulcus development in Mexican neonates and infants with congenital hypothyroidism

1, 4 / Carmen Sánchez-Pérez1 / Eugenio Morales2 / Mario Mandujano1 / Martínez-Vázquez Rosa Ivone1 / María de la Luz Ruiz-Reyes3 / Raúl Calzada-León3

1Follow-up Neurodevelopment Laboratory, Instituto Nacional de Pediatría and Universidad Autónoma Metropolitana Xochimilco, México City, México

2Radiology Department, Instituto Nacional de Pediatría, México City, México

3Endocrinology Service, Instituto Nacional de Pediatría, México City, México

4CMF Tlalpan ISSSTE, México City, México

Corresponding author: Gerardo A. Alvarado-Ruiz, Laboratorio de Seguimiento del Neurodesarrollo, Instituto Nacional de Pediatría, Insurgentes Sur 3000-C, Coyoacan CP 04530, Col. Insurgentes Cuicuilco, México City, México

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 25, Issue 1-2, Pages 89–96, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem.2011.424, December 2011

Publication History

Received:
2011-10-05
Accepted:
2011-11-08
Published Online:
2011-12-20

Abstract

Background: Ultrasonography of cortical and cingulum maturity patterns, were studied in newborns and infants with congenital hypothyroidism (CH).

Method: Transversal study of 29 newborns and infants with CH, detected by neonatal screening and confirmed with thyroid function test, thyroid ultrasonography, and thyroid scintigraphy. During the first 2 months of life, transfontanelar brain ultrasonography was performed. Brain cortex maturity was assessed by normality referents provided by Slagle and Timor methods.

Results: Cortical immaturity signs were observed in 69% of infants (20 patients with Slage’s method brain cortex development delay (Pearson’s p=0.05). Logistic nominal analysis for normality prediction demonstrated a correlation between brain cortex development and age, bone age, treatment duration, and type of CH. The most sensitive detecting technique was sagittal sight by Slagle’s method.

Conclusions: Brain cortex delayed development is frequent in children with CH. Bone age, postnatal age at treatment start, and time since treatment start, correlates with neurological development, but not athyreosis or sublingual nodule.

Keywords: brain cortex maturity; cingulum; congenital hypothyroidism; infant; newborn; transfontanelar brain ultrasound

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