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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

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Acanthosis nigricans predicts the clustering of metabolic syndrome components in Hispanic elementary school-aged children

3 / Laura Vanderbloemen1 / Betty Skipper2 / John Leggott2 / Emilie Sebesta3 / Robert Glew4 / Mark R. Burge5

1Department of Health Sciences, University of York, York, UK

2Family and Community Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA

3Department of Pediatrics, University of New Mexico School of Medicine, Albuquerque, NM, USA

4Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM, USA

5Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA

Corresponding author: Alberta S. Kong, MD, MPH, Department of Pediatrics, University of New Mexico School of Medicine, MSC 10 5590, Albuquerque, NM 87131-0001, USA, Phone: +(505) 272-4462, Fax: +(505) 272-6845

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 25, Issue 11-12, Pages 1095–1102, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem-2012-0117, October 2012

Publication History

Received:
2012-04-12
Accepted:
2012-08-04
Published Online:
2012-10-02

Abstract

Background: Acanthosis nigricans (AN) is a dermatologic condition associated with hyperinsulinemia, a marker of insulin resistance that is the principal abnormality in metabolic syndrome (MetS). We examined the association of AN with the clustering of MetS components.

Methods: A cross-sectional study was conducted in an urban school-based health center in New Mexico. Students without diabetes were evaluated for AN, a family history of type 2 diabetes, body mass index (BMI), and MetS components. The clustering of MetS components by BMI category and AN status was assessed by comparing the group means of summed average z-scores of fasting insulin, triglycerides, high-density lipoprotein-cholesterol, and systolic blood pressure among the students. A multivariate model with BMI category and AN status controlling for Tanner stage was performed to identify the variables associated with the clustering of MetS components.

Results: Complete data were available for 90 children (age, 9.7±1.4 years; 94% Hispanic; 60% female). In multivariate modeling of MetS cluster z-score, significant differences were found between the students with BMI <85th percentile [–0.27; 95% confidence interval (95% CI)=–0.42 to –0.11] and (a) the students with BMI 85th–94.9th percentile with AN (0.74; 95% CI=0.17–1.31) and (b) the students with BMI ≥95th percentile with AN (0.86; 95% CI=0.54–1.18). No significant differences in the MetS cluster z-score were seen between the students with BMI <85th percentile and those with BMI 85th–94.9th percentile without AN (0.24; 95% CI=–0.33 to 0.81) or those with BMI ≥95th percentile without AN (0.31; 95% CI=–0.13 to 0.75).

Conclusions: Overweight/obese Hispanic elementary school-aged children with AN exhibit clustering of MetS components and could benefit from early intervention.

Keywords: Acanthosis nigricans; children; Hispanic; insulin resistance; metabolic syndrome; obesity; school health services

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