Jump to ContentJump to Main Navigation

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

6 Issues per year


IMPACT FACTOR increased in 2014: 0.995

SCImago Journal Rank (SJR) 2014: 0.378
Source Normalized Impact per Paper (SNIP) 2014: 0.454
Impact per Publication (IPP) 2014: 0.880

VolumeIssuePage

Issues

Increased endothelial microparticles in obese and overweight children

Zübeyde Gündüz1 / 1 / Sebahat Tülpar1 / Funda Baştuğ1 / Ali Baykan2 / Ali Yıkılmaz3 / Türkan Patıroğlu4 / Hakan M. Poyrazoglu1 / Leyla Akın5 / Sibel Yel1 / Ruhan Düşünsel1

1Faculty of Medicine, Department of Pediatric Nephrology, Erciyes University, Kayseri, Turkey

2Faculty of Medicine, Department of Pediatric Cardiology, Erciyes University, Kayseri, Turkey

3Faculty of Medicine, Department of Pediatric Radiology, Erciyes University, Kayseri, Turkey

4Faculty of Medicine, Department of Pediatric Immunology, Erciyes University, Kayseri, Turkey

5Faculty of Medicine, Department of Pediatric Endocrinology, Erciyes University, Kayseri, Turkey

Corresponding author: İsmail Dursun, MD, Faculty of Medicine, Department of Pediatric Nephrology, Erciyes University, 38039 Kayseri, Turkey, Phone: +90-352-4374937-25464, GSM: +90-505-9067145, Fax: +90-352-4375825

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 25, Issue 11-12, Pages 1111–1117, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem-2012-0194, September 2012

Publication History

Received:
2012-06-19
Accepted:
2012-08-17
Published Online:
2012-09-15

Abstract

Background: Obesity in children increases the risk of atherosclerosis. Endothelial dysfunction is an important factor in the pathogenesis of atherosclerosis, and endothelial microparticles (EMPs) are considered as markers of endothelial dysfunction. In this study, we aimed to evaluate circulating EMPs in obese and overweight children and to disclose the measure of obesity with the strongest relation with circulating microparticles and carotid atherosclerosis.

Methods: This prospective study included 55 obese and overweight children and 23 healthy controls. Insulin resistance was studied. Both in vivo and in vitro human umbilical vein endothelial cell evaluations were used for the study. Circulating EMPs (CD144 and CD146) were measured by flow cytometry. The carotid artery intima-media thickness (cIMT) and left ventricular mass index (LVMI) were measured using ultrasound and echocardiography, respectively. Study groups were compared for anthropometric measurement, insulin resistance, circulating EMP, cIMT, and LVMI. The relationship among overweight, obesity, and circulating EMPs were investigated.

Results: Blood pressure, CD144+EMP levels, and LVMI were statistically higher in the patients group than in the control group. The multiple logistic regression analysis and the backward elimination method showed that CD144+EMP and systolic blood pressure had a linear relationship with overweight and obesity.

Conclusion: Our results suggest that endothelial damage starts in the early stage of childhood obesity and that obese and overweight children have increased circulating CD144+EMPs, showing that endothelial dysfunction and increased CD144+EMPs may be related to obesity.

Keywords: atherosclerosis; childhood obesity; endothelial microparticles; inflammation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Luc Bruyndonckx, Vicky Y. Hoymans, Geert Frederix, Ann De Guchtenaere, Hilde Franckx, Dirk K. Vissers, Christiaan J. Vrints, José Ramet, and Viviane M. Conraads
The Journal of Pediatrics, 2014, Volume 165, Number 2, Page 300
[2]
Luc Bruyndonckx, Vicky Y. Hoymans, Amaryllis H. Van Craenenbroeck, Dirk K. Vissers, Christiaan J. Vrints, José Ramet, and Viviane M. Conraads
Oxidative Medicine and Cellular Longevity, 2013, Volume 2013, Page 1

Comments (0)

Please log in or register to comment.