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Licensed Unlicensed Requires Authentication Published by De Gruyter October 2, 2012

The treatment effect of diazoxide on 44 patients with congenital hyperinsulinism

  • Shuwen Hu , Zidi Xu , Jie Yan , Min Liu , Bing Sun , Wenjing Li and Yanmei Sang EMAIL logo

Abstract

Objective: To study the treatment effect and safety of diazoxide on patients with congenital hyperinsulinism (CHI).

Research design and methods: A total of 44 patients who have been hospitalized to our hospital and used diazoxide as a trial after diagnosis of CHI were chosen as research subjects. The clinical data of the patients were analyzed, and the treatment effects and safety of diazoxide on CHI were evaluated.

Results: In the 44 patients studied, the blood glucoses of 36 cases recovered to normal level after using diazoxide, indicating that the 36 patients respond to the treatment of diazoxide. Eight cases still showed severe hypoglycemia after using diazoxide for 10 days, which indicated that the eight patients were unresponsive to diazoxide treatment. Eighteen patients suffered the side effect of fluid retention, and 12 patients suffered transient gastrointestinal reactions.

Conclusion: Diazoxide is a first-line treatment of CHI with high safety. Most of the patients with CHI were responsive to diazoxide treatment. Diazoxide should be used as a trial immediately after CHI diagnosis was made.


Corresponding author: Yanmei Sang, Department of Endocrinology, Beijing Children’s Hospital Affiliated to Capital Medical University, Fuxingmenwai Nanlishi Road 56, Beijing 100045, China

Received: 2012-7-10
Accepted: 2012-8-24
Published Online: 2012-10-02
Published in Print: 2012-12-01

©2012 by Walter de Gruyter Berlin Boston

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