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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Roth, Christian / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi

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Adiponectin and arterial stiffness in youth with type 1 diabetes: the SEARCH for Diabetes in Youth Study

1 / Lawrence M. Dolan1 / Abigail Lauer2 / Cralen Davis2 / Dana Dabelea3 / Stephen R. Daniels5 / Richard F. Hamman3 / Santica Marcovina4 / R. Paul Wadwa5 / Elaine M. Urbina1

1Department of Pediatrics, Cincinnati Children’s Hospital, University of Cincinnati College of Medicine, Cincinnati, OH, USA

2Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA

3Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO, USA

4Northwest Lipid Research Laboratories, University of Washington, Seattle, WA, USA

5Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA

Corresponding author: Amy S. Shah, MD MS, Division of Endocrinology, ML 7012, Cincinnati Children’s Hospital, 3333 Burnet Avenue, Cincinnati, OH 45229, USA Phone: +1-513-636-4744, Fax: +1-513-636-7486

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 25, Issue 7-8, Pages 717–721, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem-2012-0070, July 2012

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Persons with type 1 diabetes are at increased risk of developing vascular disease. Adiponectin concentrations may play an intermediate role in this process. We sought to determine whether adiponectin is correlated with vascular stiffness in adolescents with type 1 diabetes. Plasma adiponectin, pulse wave velocity (PWV), augmentation index (AIx-75), and brachial distensibility (BrachD) were collected in 225 adolescents. Outcomes were evaluated by sex, and regression models were used to determine whether adiponectin was an independent determinant of arterial stiffness. Males had lower adiponectin levels and stiffer vessels (lower BrachD, p<0.01) than females. Unadjusted correlations revealed that adiponectin was correlated with BrachD (p<0.01) but not PWV and AIx-75. After adjustment, adiponectin was not a significant predictor of BrachD. The most consistent predictors of increased stiffness were age, male sex, blood pressure, obesity, and total cholesterol (p<0.05). Adiponectin’s contributions to arterial stiffness appear to be masked by other cardiovascular risk factors in persons with type 1 diabetes.

Keywords: adiponectin; arterial stiffness; diabetes; pediatrics

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