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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

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Higher postprandial serum ghrelin among African-American girls before puberty

1 / Krista Casazza,1 / Paula Chandler-Laney1 / Barbara A. Gower1

1Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA

Corresponding author: Amy C. Ellis, Department of Nutrition Sciences, University of Alabama at Birmingham, 427 Webb Building, 1675 University Boulevard, Birmingham, AL 35294-3360, USA Phone: +1-205-975-9629, Fax: +1-205-934-7050

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 25, Issue 7-8, Pages 691–696, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem-2012-0081, June 2012

Publication History

Received:
2012-03-19
Accepted:
2012-05-06
Published Online:
2012-06-20

Abstract

Objective: Recent reports suggest that ghrelin regulation may differ by ethnicity and age. This study was designed to examine circulating ghrelin among overweight female African Americans across different age groups.

Methods: Eleven overweight peripubertal girls, 17 overweight pubertal girls, and a control group of 18 overweight African-American premenopausal women ingested a standard liquid meal after an overnight fast. Blood samples were obtained before the meal and for 4 h postchallenge. Participants rated appetite by a visual analog scale.

Results: Peripubertal girls demonstrated higher postprandial ghrelin and lesser ghrelin suppression compared with adults (p<0.05), corresponding with greater desire to eat across the test period (p=0.017). Fasting ghrelin tended to be inversely related to fasting estradiol (r=–0.264, p=0.076).

Conclusion: Compared with overweight African-American women, peripubertal girls had higher ghrelin as well as greater appetite after a standard meal. These results may suggest a dysregulation in ghrelin reflective of demands of growth.

Keywords: African American; estradiol; ghrelin; hunger; puberty

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