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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

12 Issues per year

IMPACT FACTOR 2012: 0.747
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18F-DOPA positron emission tomography/computed tomography application in congenital hyperinsulinism

Jigang Yang1 / Leilei Yuan1 / Jacqui K. Meeks2 / Nan Zhang1 / Chunlin Li1 / 3

1Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China

2Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA

3Medical Healthcare Center, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China

Corresponding author: Ruirui Hao, Medical Healthcare Center, Beijing Friendship Hospital of Capital Medical University, Beijing 100050, China Phone: +86-10-13121275863, Fax: +86-10-63137595

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 25, Issue 7-8, Pages 619–622, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem-2012-0114, July 2012

Publication History:
Received:
2012-04-09
Accepted:
2012-05-27
Published Online:
2012-07-13

Abstract

Congenital hyperinsulinism (CHI) during infancy is characterized by inappropriate insulin secretion resulting in persistent hypoglycemia. This can lead to irreversible severe neurological damage in the infant. There are two main histologic subtypes: diffuse and focal, both of which may require different surgical strategies. It is very important to differentiate focal leisons from diffuse leisons. However, the differentiation of diffuse leisons from focal leisons is challenging. Affected pancreatic areas utilize dihydroxyphenylalanine (DOPA) at a higher rate than normal pancreatic tissues; thus, labeling of L-DOPA with fluorine-18 (18F-DOPA) allows functional mapping of hyperinsulinism using positron emission tomography/computed tomography (PET/CT). In this article, we reviewed the 18F-DOPA PET/CT application in CHI. The aim of this review is to enhance the recognition of 18F-DOPA PET/CT application in the diagnosis of CHI.

Keywords: congenital hyperinsulinism; PET/CT; 18F-DOPA

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