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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

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Metabolic impact of a ketogenic diet compared to a hypocaloric diet in obese children and adolescents

Ioanna Partsalaki,1 / Alexia Karvela1 / 1

1Research Laboratory of the Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University of Patras School of Medicine, Patras, Achaea, Greece

Corresponding author: Bessie E. Spiliotis, Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University of Patras School of Medicine, Patras, Achaea, Greece Phone: +30-2613-603-741, Fax: +30-2610-994-533

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 25, Issue 7-8, Pages 697–704, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem-2012-0131, July 2012

Publication History

Received:
2012-04-24
Accepted:
2012-05-27
Published Online:
2012-07-05

Abstract

Background: The effects of carbohydrate-restricted (ketogenic) diets on metabolic parameters in children have been incompletely assessed.

Objective: To compare the efficacy and metabolic impact of ketogenic and hypocaloric diets in obese children and adolescents.

Subjects: Fifty-eight obese subjects were placed on one of the two diets for 6 months.

Methods: Anthropometric measurements, body composition, oral glucose/insulin tolerance test, lipidemic profile, high molecular weight (HMW) adiponectin, whole-body insulin sensitivity index (WBISI), and homeostatic model assessment-insulin resistance (HOMA-IR) were determined before and after each diet.

Results: Both groups significantly reduced their weight, fat mass, waist circumference, fasting insulin, and HOMA-IR (p=0.009 for ketogenic and p=0.014 for hypocaloric), but the differences were greater in the ketogenic group. Both groups increased WBISI significantly, but only the ketogenic group increased HMW adiponectin significantly (p=0.025).

Conclusions: The ketogenic diet revealed more pronounced improvements in weight loss and metabolic parameters than the hypocaloric diet and may be a feasible and safe alternative for children’s weight loss.

Keywords: adiponectin; adolescents; children; hypocaloric diet; insulin sensitivity; ketogenic diet; obesity

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