In congenital hypothyroidism, an initial L-thyroxine dose of 10–12 μg/kg/day is sufficient and sometimes excessive based on thyroid tests 1 month later : Journal of Pediatric Endocrinology and Metabolism Jump to ContentJump to Main Navigation
Show Summary Details

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Roth, Christian / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi


IMPACT FACTOR 2015: 0.912

SCImago Journal Rank (SJR) 2015: 0.493
Source Normalized Impact per Paper (SNIP) 2015: 0.600
Impact per Publication (IPP) 2015: 0.955

149,00 € / $224.00 / £112.00*

Online
ISSN
2191-0251
See all formats and pricing

 


Select Volume and Issue
Loading journal volume and issue information...

In congenital hypothyroidism, an initial L-thyroxine dose of 10–12 μg/kg/day is sufficient and sometimes excessive based on thyroid tests 1 month later

1 / Meenal Pathak2 / Paul B. Kaplowitz2

1Pediatric Endocrinology, Children’s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA

2Department of Endocrinology, Children’s National Medical Center, Washington, DC, USA

Corresponding author: Priya Vaidyanathan, Pediatric Endocrinology, Children’s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 25, Issue 9-10, Pages 849–852, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem-2012-0025, September 2012

Publication History

Received:
2012-01-31
Accepted:
2012-08-04
Published Online:
2012-09-06

Abstract

Background: Current guidelines recommend an initial L-thyroxine (L-T4) dose of 10–15 μg/kg/day for the treatment of congenital hypothyroidism (CH). We analyzed our data for the treatment outcome at 1 month after we noted a frequent overtreatment even at the lower end of this dose range.

Methods: A 3-year chart review of 55 patients with confirmed CH was performed. The patients were divided to three groups based on L-T4 dose: Group 1 (6–9.9 μg/kg), Group 2 (10–11.9 μg/kg), and Group 3 (12–15 μg/kg). Overtreatment was defined as T4>16 μg/dL/free T4>2.3 ng/dL±thyroid-stimulating hormone (TSH) <0.5 μIU/L and undertreatment was defined as TSH>6 μIU/L at 1 month.

Results: At 1 month, 45.8%, 37.5%, and 16.6% in Group 1, 30%, 55%, and 15% in Group 2, and 0%, 75%, and 25% in Group 3 had target labs, overtreatment, and undertreatment, respectively.

Conclusions: An initial L-T4 dose of 10–11.9 μg/kg for TSH>100 μIU/L and 8–10 μg/kg for TSH<100 μIU/L at diagnosis met and often exceeded the target thyroid levels at 1 month. More frequent overtreatment was seen when >12 μg/kg was given.

Keywords: congenital; hypothyroidism; L-thyroxine dose

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]

Comments (0)

Please log in or register to comment.