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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

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Relationship between left ventricular mass and carotid intima media thickness in obese adolescents with non-alcoholic fatty liver disease

1 / Ozgur Pirgon2 / Ebru Aypar1 / Hakan Yilmaz3 / Dursun Odabas1

1Department of Pediatric Cardiology, Konya Training and Research Hospital, Konya, Turkey

2Faculty of Medicine, Department of Pediatric Endocrinology, S. Demirel University, Isparta, Turkey

3Department of Radiology, Konya Training and Research Hospital, Konya, Turkey

Corresponding author: Ahmet Sert, Department of Pediatric Cardiology, Konya Training and Research Hospital, 42080, Konya, Turkey, Phone: +90 332 323 67 09, Fax: +90 332 323 67 23

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 25, Issue 9-10, Pages 927–934, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem-2012-0187, September 2012

Publication History

Received:
2012-06-13
Accepted:
2012-08-12
Published Online:
2012-09-06

Abstract

Background/aims: No data are available examining the relationship between carotid intima media thickness (IMT) and left ventricular mass (LVM) in obese adolescents with non-alcoholic fatty liver disease (NAFLD). Therefore, we investigated LVM and carotid IMT in obese adolescents with NAFLD.

Methods: Eighty obese adolescents and 37 lean subjects were enrolled in the study. The obese subjects were divided into two subgroups based on the presence or absence of fatty liver with high transaminases (NAFLD group and non-NAFLD group). Fasting blood samples were assayed for serum transaminases, glucose and insulin levels. Insulin resistance was calculated by the homeostasis model assessment (HOMA-IR).

Results: LVM measurements were higher in both NAFLD and non-NAFLD obese patients in comparison with the lean children. The NAFLD group had significantly higher LVM measurements than the non-NAFLD and lean groups. Carotid IMT was higher in both the NAFLD and non-NAFLD obese patients in comparison with the lean group. The NAFLD group had significantly higher carotid IMT measurements than the non-NAFLD and lean groups. LVM was positively correlated with HOMA-IR and serum alanine aminotransferase levels in the NAFLD obese group. Carotid IMT was positively correlated with HOMA-IR, serum alanine aminotransferase levels and LVM in the NAFLD obese group.

Conclusions: We demonstrated that obese adolescents with NAFLD have increased LVM and carotid IMT and low insulin sensitivity. Obese adolescents with NAFLD and increased carotid IMT may demonstrate a more adverse cardiovascular risk profile and higher LVM. Therefore, assessment of carotid IMT, in addition to echocardiography, may assist in risk stratification in obese adolescents with NAFLD with elevated cardiovascular risk factor levels.

Keywords: adolescent; carotid intima media thickness; insulin resistance; left ventricular mass; non-alcoholic fatty liver disease

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