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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

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Absence of diabetes mellitus type 2 in obese children and adolescents in the north of Spain

Aníbal Aguayo1, 2, a / Amaia Vela1, 2, a / Angeles Aniel-Quiroga2, 3 / Elizabeth Blarduni4 / Concepción Fernández5 / Gema Grau1 / Javier Núñez6 / Pedro Martul1, 2 / Luis Castaño2, 7 / 1, 2

1Paediatric Endocrinology Unit, Cruces University Hospital, UPV/EHU, Barakaldo, Spain

2Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Bilbao, Spain

3Service Biochemistry, Hormone Laboratory, Cruces University Hospital, UPV/EHU, Barakaldo, Spain

4Paediatric Service, Zumarraga Hospital, Zumarraga, Spain

5Paediatric Endocrinology Unit, Basurto University Hospital, Bilbao, Spain

6Paediatric Service, Mendaro Hospital, Mendaro, Spain

7Research Unit, Cruces University Hospital, UPV/EHU, Barakaldo, Spain

aThese authors contributed equally to this work.

Corresponding author: Itxaso Rica, MD, PhD, Paediatric Endocrinology Unit, Hospital Universitario Cruces, Plaza de Cruces s/n, 48903, Barakaldo, Bizkaia, Spain

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 26, Issue 1-2, Pages 25–29, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem-2012-0200, December 2012

Publication History

Received:
2012-06-21
Accepted:
2012-10-05
Published Online:
2012-12-06

Abstract

Background: The worldwide epidemic of childhood obesity has been accompanied by an increase in the incidence of carbohydrate metabolism disorders.

Objective: To determine the prevalence of type 2 diabetes mellitus (T2DM) and other carbohydrate metabolism disorders in obese young people in the Basque Country (Spain).

Design: Prospective observational study.

Patients: We studied 136 obese Caucasian children and adolescents (body mass index ≥2 SDS above the mean).

Measurements: Their severity of obesity was classified as mild <3 SDS or moderate-to-severe ≥3 SDS. Data were collected on clinical and metabolic parameters; insulin resistance (IR) was calculated using the homeostasis model assessment, and an oral glucose tolerance test (OGTT) was carried out.

Results: T2DM was not found. Impaired glucose tolerance (IGT) was found in 9.6% of patients being higher in moderate-to-severe obesity (12.8% vs. 2.4%; p=0.048) and in patients with acanthosis nigricans (27.8% vs. 6.8%; p=0.016). No differences were detected by sex or pubertal development in metabolic results as a function of OGTT’s response. IR (13.5%) was higher among those with moderate-to-severe obesity, in patients with acanthosis nigricans and was associated with other cardiovascular disease risk factors.

Conclusions: We found no children with T2DM. The prevalence of IGT and IR was related to severity of obesity, to the association of acanthosis nigricans and was associated with cardiovascular risk.

Keywords: childhood; glucose intolerance; insulin resistance; obesity; type 2 diabetes mellitus

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