Journal of Pediatric Endocrinology and Metabolism
Editor-in-Chief: Kiess, Wieland
Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Roth, Christian / Toppari, Jorma
Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi
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Absence of diabetes mellitus type 2 in obese children and adolescents in the north of Spain
1Paediatric Endocrinology Unit, Cruces University Hospital, UPV/EHU, Barakaldo, Spain
2Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Bilbao, Spain
3Service Biochemistry, Hormone Laboratory, Cruces University Hospital, UPV/EHU, Barakaldo, Spain
4Paediatric Service, Zumarraga Hospital, Zumarraga, Spain
5Paediatric Endocrinology Unit, Basurto University Hospital, Bilbao, Spain
6Paediatric Service, Mendaro Hospital, Mendaro, Spain
7Research Unit, Cruces University Hospital, UPV/EHU, Barakaldo, Spain
aThese authors contributed equally to this work.
Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 26, Issue 1-2, Pages 25–29, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem-2012-0200, December 2012
- Published Online:
Background: The worldwide epidemic of childhood obesity has been accompanied by an increase in the incidence of carbohydrate metabolism disorders.
Objective: To determine the prevalence of type 2 diabetes mellitus (T2DM) and other carbohydrate metabolism disorders in obese young people in the Basque Country (Spain).
Design: Prospective observational study.
Patients: We studied 136 obese Caucasian children and adolescents (body mass index ≥2 SDS above the mean).
Measurements: Their severity of obesity was classified as mild <3 SDS or moderate-to-severe ≥3 SDS. Data were collected on clinical and metabolic parameters; insulin resistance (IR) was calculated using the homeostasis model assessment, and an oral glucose tolerance test (OGTT) was carried out.
Results: T2DM was not found. Impaired glucose tolerance (IGT) was found in 9.6% of patients being higher in moderate-to-severe obesity (12.8% vs. 2.4%; p=0.048) and in patients with acanthosis nigricans (27.8% vs. 6.8%; p=0.016). No differences were detected by sex or pubertal development in metabolic results as a function of OGTT’s response. IR (13.5%) was higher among those with moderate-to-severe obesity, in patients with acanthosis nigricans and was associated with other cardiovascular disease risk factors.
Conclusions: We found no children with T2DM. The prevalence of IGT and IR was related to severity of obesity, to the association of acanthosis nigricans and was associated with cardiovascular risk.
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