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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

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Detection of vascular risk markers in children and adolescents with type 1 diabetes

1 / Ayla Güven1 / Metin Yıldız1 / Fatma Dursun1 / Nurcan Cebeci1 / Suna Hancili1

1Göztepe Educational and Research Hospital, Clinics of Pediatric Endocrinology, Istanbul, Turkey

Corresponding author: Dr. Heves Kırmızıbekmez, Göztepe Educational and Research Hospital, Clinics of Pediatric Endocrinology, Dr Erkin Caddesi, Kadıköy, Istanbul, Turkey, Phone: +90 216 3910680 (1374), Fax: +90 216 3910690, E-mail:

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 27, Issue 1-2, Pages 87–92, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem-2013-0046, August 2013

Publication History

Received:
2012-11-28
Accepted:
2013-07-16
Published Online:
2013-08-14

Abstract

Objectives: Type 1 diabetes is a chronic disease that causes persistent vascular injury. This study investigates the benefits of surrogate markers in early detection of vascular injury in children and adolescents with type 1 diabetes.

Methods: Eighty-four patients (35 male, 49 female) with type 1 diabetes for 5 or more years were included. Serum lipid profile, plasminogen activator inhibitor-1 (PAI-1), lipoprotein (a) (Lpa) and homocystein, were investigated. Patients were divided into two groups according to the duration of diabetes. Patients with and without microvascular complications were also compared.

Results: Microvascular complications were present in 14 out of 48 patients in group-1 (29.1%; duration of diabetes: 5–10 years) and in 7 out of 36 patients in group-2 (19.4%; duration of diabetes: >10 years). Serum homocystein, Lpa, PAI-1 and serum lipids were not correlated with the duration of diabetes. Significantly increased triglyceride (TG) and HbA1C levels were associated with the presence of microvascular complications.

Conclusion: Providing good glycemic control is very important for preventing vascular injury in children and adolescents with type 1 diabetes. It seems that traditional vascular surrogate markers like LDL/HDL ratio, triglycerides and HbA1C level correspond more to microvascular complications than newly defined surrogate markers that are not commonly available.

Keywords: children and adolescents; type 1 diabetes; vascular complications

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