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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, M.J.M.C. / Kurjak M.D., Asim / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, MD, PhD, HonD, Istvan / Vetter, Klaus / Winn, MD, Hung N. / Young, Bruce K. / Zimmermann, Roland

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Guideline for the use of antenatal corticosteroids for fetal maturation

Xavier Miracle1 / Gian Carlo Di Renzo2 / Ann Stark3 / Avroy Fanaroff4 / Xavier Carbonell-Estrany5 / Erich Saling (Coordinators of WAPM Prematurity working group)6

1Neonatology Service, Hospital Clinic, Institut Clinic de Ginecologia, Obstetricia I Neonatologia, Universitat de Barcelona, Barcelona, Spain

2Department of Obstetrics and Gynecology and Center for Perinatal and Reproductive Medicine, University of Perurgia, Italy

3Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA

4Rainbow Babies and Children's Hospital, Cleveland, Ohio and Case Western Reserve University School of Medicine, USA

5Neonatology Service, Hospital Clinic, Institut Clinic de Ginecologia, Obstetricia I Neonatologia, Universitat de Barcelona, Barcelona, Spain

6Institute of Perinatal Medicine, Berlin, Neukoelln

Corresponding author: Dr. Xavier Miracle Neonatal Department Hospital Clínic de Barcelona (Seu Maternitat) Carrer Sabino Arana 1 08028 Barcelona Tel: +3493 2275600 Ext: 7443-7503 Fax: +3493 2275605

Citation Information: Journal of Perinatal Medicine. Volume 36, Issue 3, Pages 191–196, ISSN (Online) 16193997, ISSN (Print) 0300-5577, DOI: 10.1515/JPM.2008.032, May 2008

Publication History

Published Online:


The aim is to present a document, which is based on current evidence and serves as a guideline for use in clinical practice. The following questions are addressed:

• Is the use of antenatal corticosteroids (ACS) an effective therapy?

• Who are the candidates for antenatal corticosteroid therapy?

• Is there benefit after 34 weeks' gestation?

• When is the optimal time to treat?

• Which are the optimal steroids; what is the ideal dose and route of administration?

• Are there any contraindications to the administration of ACS?

• Are antenatal corticosteroids indicated in women with premature rupture of membranes (PROM)?

• Is the use of ACS recommended in pregnancies complicated by maternal diabetes mellitus?

• Should the treatment with corticosteroids be repeated?

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