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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, M.J.M.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

6 Issues per year


IMPACT FACTOR 2014: 1.358
5-year IMPACT FACTOR: 1.597

SCImago Journal Rank (SJR) 2014: 0.731
Source Normalized Impact per Paper (SNIP) 2014: 0.687
Impact per Publication (IPP) 2014: 1.483

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Real-time optical imaging of experimental brain ischemia and hemorrhage in neonatal piglets

M. R. Stankovic / D. Maulik / W. Rosenfeld / P. G. Stubblefield / A. D. Kofinas / S. Drexler / R. Nair / M. A. Franceschini / D. Hueber / E. Gratton / S. Fantini

Citation Information: Journal of Perinatal Medicine. Volume 27, Issue 4, Pages 279–286, ISSN (Print) 0300-5577, DOI: 10.1515/JPM.1999.039, June 2005

Publication History

Published Online:
2005-06-01

Abstract

Our objective was to study the development of experimental brain ischemia and hemorrhage by real-time optical imaging. Optical imaging is based on the ability of near infrared light to non-invasively penetrate through the intact scalp and skull and measure brain concentrations of oxy- and deoxyhemoglobin, dominant brain absorbers. Optical imaging was performed in 7 anesthetized, instrumented, and ventilated newborn piglets subjected to the injection of 0.3 cc of saline followed by 2 cc of blood into the left frontal subcortical brain region via a needle inserted through the skull with stereotactic guidance. The image-acquisition rate of 5.26 images per sec allowed for real-time imaging. The detection threshold of the imager at the estimated depth of 1–1.5 cm was ∼, 70 μL for saline and ∼,40 μL for blood. The imager readily detected five subcortical hematomas and two large bilateral subarachnoid hemorrhages. The imager detected a global decrease in brain absorption associated with the volume-injection-related increase in intracranial pressure in the surrounding ipsi- lateral and contralateral brain. Any decrease in brain absorption is an equivalent to brain ischemia. This study demonstrates the capability of optical imaging in detecting brain ischemia and hemorrhage in real-time with high temporal and spatial resolution.

Citing Articles

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Khadija Tahir and Christopher Dainty
Journal of Optics A: Pure and Applied Optics, 2005, Volume 7, Number 5, Page 207
[6]
D M Hueber, M A Franceschini, H Y Ma, Q Zhang, J R Ballesteros, S Fantini, D Wallace, V Ntziachristos, and B Chance
Physics in Medicine and Biology, 2001, Volume 46, Number 1, Page 41
[7]
Miljan R. Stankovic, Dev Maulik, Warren Rosenfeld, Phillip G. Stubblefield, Alexander D. Kofinas, Enrico Gratton, Maria Angela Franceschini, Sergio Fantini, and Dennis M. Hueber
The Journal of Maternal-Fetal Medicine, 2000, Volume 9, Number 2, Page 142

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