Abstract

Aims: To investigate localization and concentration of adhesion molecules in the human lower uterine segment during preterm parturition.

Methods: In a prospective study biopsy specimens from the lower uterine segment of 43 patients undergoing cesarean section at 24 + 0 to 36 + 4 weeks' gestation were immunostained for intercellular adhesion molecule-1, endothelial leukocyte adhesion molecule-1, vascular cell adhesion molecule-1, and platelet endothelial cell adhesion molecule-1, and the concentrations measured by enzyme immunoassay. The results were analyzed in relation to the degree of cervical dilatation (< 2 cm, 2 – < 4 cm, ≥ 4 cm) and duration of labor (≤ 6 h, > 6–12 h; > 12 h).

Results: Intercellular adhesion molecule-1 and platelet endothelial cell adhesion molecule-1 were strongly expressed by capillary endothelium, endothelial leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1 to only a minor degree. Intercellular adhesion molecule-1 concentration was greater at ≥ 4 cm dilatation than at 2– < 4 cm and after > 12 h labor than after ≤ 6 h. Endothelial leukocyte adhesion molecule-1 concentration was greater after >12 h than after ≤ 6 h.

Conclusions: Premature labor is associated with up-regulation of adhesion molecules in the lower uterine segment.