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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, M.J.M.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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β2-adrenergic receptor gene polymorphisms and pregnancy outcome

Kunihiko Doh1 / Istvan Sziller2 / Santosh Vardhana3 / Eszter Kovacs4 / Zoltan Papp5 / Steven S. Witkin6







Corresponding author: Dr. Steven S. Witkin, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, 525 East 68th Street, Box 35 New York, New York, 10021/U.S.A. Tel.: +1 (212) 746 3165, Fax: +1 (212) 746 8799, E-mail:

Citation Information: Journal of Perinatal Medicine. Volume 32, Issue 5, Pages 413–417, ISSN (Print) 0300-5577, DOI: 10.1515/JPM.2004.138, June 2005

Publication History

October 20, 2003
April 2, 2004
April 6, 2004
Published Online:


Aims: The association between alleles at two loci of the polymorphic β2-adrenergic receptor (β2AR) gene and pregnancy outcome was determined.

Methods: In a case-control study, buccal swabs obtained from 159 mother-infant pairs after a preterm or term birth were analyzed by gene amplification and endonuclease digestion for polymorphisms at codons 16 and 27 of the β2AR gene.

Results: Homozygosity for allele A at codon 16 (Arg-16) occurred in 26 (20.5%) of 127 mothers with a term birth and in none of the mothers who had a spontaneous preterm birth (p = 0.002). Conversely, 24 of 32 (75.0%) mothers with a spontaneous preterm birth, as compared to 58 of 127 (45.7%) mothers with term births, were Arg-16/allele G (Gly-16) heterozygotes (p = 0.003). There was no relation between pregnancy outcome and infant genotype at codon 16 or maternal or infant genotypes at codon 27. The alleles at codon 16 and 27 were in linkage disequilibrium and the combinations of Arg-16-Gln-27 homozygosity (p = 0.04) and Arg-16/Gly-16-Gln homozygous (p = 0.01) were associated with a decreased and increased rate of spontaneous preterm birth, respectively.

Conclusion: At codon 16 of the β2-AR gene, maternal Arg-16 homozygosity protects against, and Gly-16 predisposes to spontaneous preterm birth.

Keywords: β2-adrenergic receptor; genetic polymorphism; pregnancy; spontaneous preterm birth

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