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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Aslam, Muhammad / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / Dimitrou, G. / Grunebaum, G. E. / Harding, Jane / Hentschel, Roland / Kawabata, Ichiro / Keirse, M.J.M.C. / Kurjak M.D., Asim / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Geijn, Herman P. / Vetter, Klaus / Young, Bruce K. / Zimmermann, Roland / Köpcke, W.

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Increased IMPACT FACTOR 2012: 1.949
Rank 29 out of 77 in category Obstretics & Gynecology and 39 out of 121 in category Pediatrics in the 2012 Thomson Reuters Journal Citation Report/Science Edition



IL-8 concentrations in maternal serum, amniotic fluid and cord blood in relation to different pathogens within the amniotic cavity

Armin Witt1 / Angelika Berger2 / Christian J. Gruber3 / Ljubomir Petricevic4 / Petra Apfalter5 / Peter Husslein6







Corresponding author: Armin Witt, MD, University of Vienna Medical School, Department of Obstetrics and Gynecology, Währinger Gürtel 18-20, A -1090 Vienna/Austria. Tel.: +43-1-40400-2822; Fax.: +43-1-40400-2861;

Citation Information: Journal of Perinatal Medicine. Volume 33, Issue 1, Pages 22–26, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: 10.1515/JPM.2005.003, June 2005

Publication History:
June 1, 2004
September 30, 2004
Published Online:


Objective: The association between elevated interleukin (IL)-8 concentrations in amniotic fluid and preterm delivery is well described. Little consideration has been given to the impact of different groups of microorganisms within the amniotic cavity on IL-8 concentration.

Methods: We collected amniotic fluid, placental tissue and amniotic membranes during preterm cesarean sections for bacterial culture. In addition, we determined IL-8 concentrations in maternal serum, amniotic fluid and cord blood and correlated them with the various intra-amniotic pathogens isolated by bacterial culture.

Results: IL-8 concentrations were determined in amniotic fluid in 107 cases, in cord blood in 185 cases and in maternal blood in 158 cases. Women with intra-amniotic Ureaplasma urealyticum infection had significantly higher amniotic fluid concentrations of IL-8 than those without (P<0.001). In cord blood, we found significantly elevated IL-8 concentrations due to intra-amniotic infection with U. urealyticum (P=0.045) and other pathogens (P=0.04). In maternal sera, we found no significant elevation of maternal IL-8 in any of the groups.

Conclusion: Intrauterine infection with U. urealyticum seems to play a profound role in the cascade of inflammation and increases IL-8 concentrations in amniotic fluid and cord blood.

Keywords: Amniotic cavity; cesarean section; interleukin-8; preterm delivery; Ureaplasma urealyticum

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