Gender dependent association between perinatal morbidity and estrogen receptor-alpha Pvull polymorphism : Journal of Perinatal Medicine uses cookies, tags, and tracking settings to store information that help give you the very best browsing experience.
To understand more about cookies, tags, and tracking, see our Privacy Statement
I accept all cookies for the De Gruyter Online site

Jump to ContentJump to Main Navigation

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, M.J.M.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

IMPACT FACTOR 2014: 1.358
5-year IMPACT FACTOR: 1.597

SCImago Journal Rank (SJR) 2014: 0.731
Source Normalized Impact per Paper (SNIP) 2014: 0.687
Impact per Publication (IPP) 2014: 1.483



30,00 € / $42.00 / £23.00

Get Access to Full Text

Gender dependent association between perinatal morbidity and estrogen receptor-alpha Pvull polymorphism

László Derzbach1 / András Treszl2 / Ádám Balogh3 / Barna Vásárhelyi4 / Tivadar Tulassay5 / János Rigó J.6







Corresponding author: László Derzbach, M.D. Ist Department of Pediatrics Semmelweis University Budapest Hungary

Citation Information: Journal of Perinatal Medicine. Volume 33, Issue 5, Pages 461–462, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: 10.1515/JPM.2005.082, October 2005

Publication History

February 16, 2005
April 19, 2005
April 23, 2005


Aims: Assuming the importance of estrogen in perinatal physiology, we tested the association of an estrogen receptor-alpha (ER-alpha) gene Pvull pP polymorphism with perinatal morbidity in premature infants.

Methods: The ER-alpha Pp genotype was determined in 69 low-birth weight (LBW) boys and 72 LBW girls, 86 term boys and 81 term girls. The association between risk factors, genotype, gender and perinatal morbidity was tested with binary logistic regression analysis.

Results: Boys carrying “p” allele were at lower risk for necrotizing enterocolitis (OR [95% Cl]: 0.24 [0.07–0.83]) and patent ductus arteriosus (OR [95% Cl]: 0.24 [0.05–0.97]). The carrier state of the “p” allele was associated with a 34-h shorter period of oxygen supplementation on average (P=0.0018). Boys with pp genotype were at greater risk for intraventricular hemorrhage (OR [95% Cl]: 4.39 [1.15–16.82]). No association between ER-alpha Pvull polymorphism and morbidity was present in girls.

Conclusions: Since homozygocity for any Pvull alleles (i.e. having PP or pp genotype) increases the risk for at least one of the most common perinatal complications, it is likely that the heterozygous carrier state of Pvull genotypes has a protective effect, which is gender-dependent.

Keywords: Estrogen receptor-alpha; polymorphism; preterm; preterm morbidity

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Negin Anousha, Arash Hossein-Nezhad, Firouzeh Biramijamal, Ali Rahmani, Zhila Maghbooli, Elahe Aghababaei, and Shahram Nemati
BioMed Research International, 2013, Volume 2013, Page 1
Ulrika Ådén, Aiping Lin, Waldemar Carlo, Alan Leviton, Jeffrey C. Murray, Mikko Hallman, Richard P. Lifton, Heping Zhang, and Laura R. Ment
The Journal of Pediatrics, 2013, Volume 163, Number 5, Page 1503
Donald C. McCurnin, Richard A. Pierce, Brigham C. Willis, Ling Yi Chang, Bradley A. Yoder, Ivan S. Yuhanna, Philip L. Ballard, Ronald I. Clyman, Nahid Waleh, William Maniscalco, James D. Crapo, Peter H. Grubb, and Philip W. Shaul
American Journal of Respiratory and Critical Care Medicine, 2009, Volume 179, Number 6, Page 492
Hanine Hajj and John M. Dagle
Seminars in Perinatology, 2012, Volume 36, Number 2, Page 98
Nahid Waleh, Ryan Hodnick, Nami Jhaveri, Suzanne McConaghy, John Dagle, Steven Seidner, Donald McCurnin, Jeffrey C Murray, Robin Ohls, and Ronald I Clyman
Pediatric Research, 2010, Volume 68, Number 4, Page 292
J S Mercer, B R Vohr, D A Erickson-Owens, J F Padbury, and W Oh
Journal of Perinatology, 2010, Volume 30, Number 1, Page 11
Géza Bokodi, András Treszl, Lajos Kovács, Tivadar Tulassay, and Barna Vásárhelyi
Pediatric Pulmonology, 2007, Volume 42, Number 10, Page 952

Comments (0)

Please log in or register to comment.