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Publication Date:
December 2005
ISSN:
1619-3997
DOI:
10.1515/JPM.2005.085

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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Aslam, Muhammad / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Brezinka, Christoph / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / Dimitrou, G. / Foulon, Walter / Grunebaum, G. E. / Harding, Jane / Hentschel, Roland / Kawabata, Ichiro / Keirse, M.J.M.C. / Kurjak M.D., Asim / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Nishida, Hiroshi / Papp, Zoltán / Makatsariya, Alexander / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Geijn, Herman P. / Vetter, Klaus / Young, Bruce K. / Zimmermann, Roland / Köpcke, W.

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The role of Fas mediated apoptosis in preeclampsia

Donna M. Neale1 / Gil Mor2

1.

2.

Corresponding author: Donna M. Neale, MD Department of Gynecology and Obstetrics, John Hopkins University School of Medicine 600 Wolfe Street Baltimore, MD 21287/USA Tel.: +1 410 955-8496 Fax: +1 410 614-8305

Citation Information: Journal of Perinatal Medicine. Volume 33, Issue 6, Pages 471–477, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: 10.1515/JPM.2005.085, December 2005

Publication History:
Published Online:
2005-12-01

Abstract

It has become clear in recent years that apoptosis is a normal process in trophoblast turnover during pregnancy. Increased trophoblast apoptosis has been observed in the placenta of women with preeclampsia, serum from women with preeclampsia has been found to induce increased trophoblast sensitivity to Fas-mediated apoptosis, and serum from women with preeclampsia has elevated levels of various chemokines, growth factors and cytokines that are involved in the regulation of apoptosis. This review highlights the importance of apoptosis in normal placental development and explores the mechanisms whereby Fas-mediated apoptosis may play a role in conditions related to abnormal placentation, such as preeclampsia.

Keywords: Gynecology; preeclampsia; trophoblast

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