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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, M.J.M.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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Accuracy and influence of ascorbic acid on glucose-test with urine dip sticks in prenatal care

Claudia Ritterath1 / Tina Siegmund2 / Neda Talai Rad3 / Ursula Stein4 / Kai J. Buhling5






Corresponding author: Kai J. Buhling, MD, PhD Clinic of Obstetrics, Charité–Universitätsmedizin Campus Virchow-Klinikum Augustenburger Platz 1, D-13353 Berlin, Germany Tel.: +49 30 450 64072 Fax: +49 30 450 64901

Citation Information: Journal of Perinatal Medicine. Volume 34, Issue 4, Pages 285–288, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: 10.1515/JPM.2006.054, July 2006

Publication History

January 30, 2006
March 25, 2006
Published Online:


Objective: In Germany, urine analysis with dip sticks are used for screening of gestational diabetes. Our goal was to find the cut-off levels of glucose dip sticks and evaluate the influence of ascorbic acid on the result.

Study design: We took urine samples of 152 pregnant patients between 01/2004 and 10/2004. The glucose content of the urine was analyzed using several dip sticks (Combur10® Roche®, Multistix® 8SG Bayer®, Diabur5000® Roche®) and by the hexokinase method. The ascorbic acid concentration of the specimen was determined.

Results: Glycosuria test dip sticks have a good sensitivity and specificity of the expected positive/negative-reaction compared with the hexokinase method but showed a significant reduction of the color reaction at high concentrations of ascorbic acid.

Conclusion: High ascorbic acid concentrations cause a reduction in the color reaction of urine dip sticks. False-negative test stick measurements can appear in patients with low glycosuria. The rate of glycosuria shows high individual differences and dependent on the concentration of vitamin C. We conclude that dip sticks are not useful in prenatal management.

Keywords: Ascorbic acid; gestational diabetes; glycosuria; pregnancy; screening

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