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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, M.J.M.C. / Kurjak M.D., Asim / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

7 Issues per year


IMPACT FACTOR 2013: 1.425

SCImago Journal Rank (SJR): 0.782
Source Normalized Impact per Paper (SNIP): 0.928

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Issues

Role of visfatin, insulin-like growth factor-I and insulin in fetal growth

Despina D. Briana1 / Maria Boutsikou2 / Dimitrios Gourgiotis3 / Louiza Kontara4 / Stavroula Baka5 / Nicoletta Iacovidou6 / Dimitrios Hassiakos7 / Ariadne Malamitsi-Puchner8

12nd Department of Obstetrics and Gynecology, Neonatal Division, Athens University Medical School, Athens, Greece

22nd Department of Obstetrics and Gynecology, Neonatal Division, Athens University Medical School, Athens, Greece

32nd Department of Pediatrics, Research Laboratories, Athens University Medical School, Athens, Greece

42nd Department of Obstetrics and Gynecology, Neonatal Division, Athens University Medical School, Athens, Greece

52nd Department of Obstetrics and Gynecology, Neonatal Division, Athens University Medical School, Athens, Greece

62nd Department of Obstetrics and Gynecology, Neonatal Division, Athens University Medical School, Athens, Greece

72nd Department of Obstetrics and Gynecology, Neonatal Division, Athens University Medical School, Athens, Greece

82nd Department of Obstetrics and Gynecology, Neonatal Division, Athens University Medical School, Athens, Greece

Corresponding author: Ariadne Malamitsi-Puchner, MD 19, Soultani Street GR-10682 Athens Greece Tel.: +30 6944443815 Fax: +30 2107233330 ;

Citation Information: Journal of Perinatal Medicine. Volume 35, Issue 4, Pages 326–329, ISSN (Online) 03005577, ISSN (Print) 16193997, DOI: 10.1515/JPM.2007.071, July 2007

Publication History

Received:
2006-11-30
Revised:
2007-03-02
Accepted:
2007-04-18
Published Online:
2007-07-05

Abstract

Objective: IGF-I and insulin are the main regulators of intrauterine and postnatal growth. Adipose tissue secreted cytokines are implicated in intrauterine growth. The relevant function of the adipocytokine visfatin is unknown.

Materials and methods: Serum visfatin, IGF-I and insulin levels were measured by enzyme immunoassays in 40 singleton full-term fetuses and neonates on postnatal days 1(N1) and 4 (N4).

Results: No significant correlations exist between visfatin and IGF-I or insulin. N1 and N4 visfatin positively correlated with customized (adjusted) birth weight centiles (r=0.511, P=0.021, and r=0.597, P=0.005, respectively). Fetal and N1 IGF-I positively correlated with customized centiles (r=0.608, P<0.001 and r=0.485, P=0.006, respectively). Fetal insulin positively correlated with customized centiles (r=0.654, P=0.021).

Conclusions: Potential implication of visfatin in fetal growth is probably not mediated by IGF-I or insulin. Although a more active role cannot be excluded, visfatin may simply represent a marker of fat accumulation.

Keywords: Fetus; IGF-I; insulin; intrauterine growth restriction; neonate; visfatin

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