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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, M.J.M.C. / Kurjak M.D., Asim / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, MD, PhD, HonD, Istvan / Vetter, Klaus / Winn, MD, Hung N. / Young, Bruce K. / Zimmermann, Roland

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Mortality and morbidity of neonates born at <26 weeks of gestation (1998–2003). A population-based study

Eva Landmann1 / Björn Misselwitz2 / Jens O. Steiss3 / Ludwig Gortner4

1Pediatric Center, Department of Pediatrics and Neonatology, Giessen, Germany

2Institute of Quality Assurance, Hesse, Germany

3Pediatric Center, Department of Pediatrics and Neonatology, Giessen, Germany

4Department of General Pediatrics and Neonatology, Saarland University Children's Hospital, Homburg/Saar, Germany

Corresponding author: Eva Landmann, MD, MPH Pediatric Center Department of Pediatrics and Neonatology Feulgenstrasse 12 35392 Giessen/Germany

Citation Information: Journal of Perinatal Medicine. Volume 36, Issue 2, Pages 168–174, ISSN (Online) 16193997, ISSN (Print) 03005577, DOI: 10.1515/JPM.2008.016, March 2008

Publication History

Published Online:


Objective: To describe mortality and morbidity of neonates born at <26 weeks' gestation in a contemporary population-based cohort.

Methods: We analyzed data of neonates born at <26 weeks between 1998 and 2003 in the Federal State of Hesse, Germany. Survival was calculated at 28 days and at discharge from hospital.

Results: Out of a total of 800 births, 572 infants were liveborn. Among those admitted for neonatal intensive care, 62.3% survived until day 28. Among the neonates followed until death or discharge, 59.6% were discharged home. Logistic regression analyses showed the following variables to be associated with an increased risk of death: Twins (Odds Ratio (OR) 3.7; 95% Confidence Interval (CI) 1.34–10.26), multiple birth ≥3 (OR 8.14; CI 1.23–53.86), intraventricular hemorrhage (IVH) ≥grade III (OR 4.79; CI 1.89–12.14), clinical risk index for babies score >15 (OR 2.9; CI 1.09–7.76), and a gestational age ≤23 weeks (OR 5.34; CI 1.24–22.98). Among infants discharged home, bronchopulmonary dysplasia was diagnosed in 52.2%, IVH ≥grade III and/or periventricular leukomalacia in 15%, and severe retinopathy of prematurity in 29.8%.

Conclusions: This study provides outcome data derived from a contemporary population-based cohort. Mortality and complication rates remain high.

Keywords: Bronchopulmonary dysplasia; intraventricular hemorrhage; neonatal survival; preterm infants

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