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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Aslam, Muhammad / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / Dimitrou, G. / Grunebaum, G. E. / Harding, Jane / Hentschel, Roland / Kawabata, Ichiro / Keirse, M.J.M.C. / Kurjak M.D., Asim / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Geijn, Herman P. / Vetter, Klaus / Young, Bruce K. / Zimmermann, Roland / Köpcke, W.

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Increased IMPACT FACTOR 2012: 1.949
Rank 29 out of 77 in category Obstretics & Gynecology and 39 out of 121 in category Pediatrics in the 2012 Thomson Reuters Journal Citation Report/Science Edition



Fetal electrocardiographic monitoring during labor in relation to cord blood levels of the brain-injury marker protein S-100

Andrea Stuart1 / Linda Edvinsson2 / Karin Källen3 / Per Olofsson4 / Charlotte Hellsten5 / Isis Amer-Wåhlin6

1Department of Obstetrics and Gynecology, Lund University Hospital, Lund, Sweden

2Department of Obstetrics and Gynecology, Lund University Hospital, Lund, Sweden

3Centre for Reproductive Epidemiology (Tornblad's Institute), Lund University Hospital, Lund, Sweden

4Department of Obstetrics and Gynecology, Malmö University Hospital, Malmö, Sweden

5Department of Obstetrics and Gynecology, Malmö University Hospital, Malmö, Sweden

6Department of Women and Child Health, Karolinska University Hospital, Stockholm, Sweden

Corresponding author: Isis Amer-Wåhlin Department of Obstetrics and Gynecology Karolinska University Hospital SE-171 76 Stockholm Sweden

Citation Information: Journal of Perinatal Medicine. Volume 36, Issue 2, Pages 136–141, ISSN (Online) 16193997, ISSN (Print) 03005577, DOI: 10.1515/JPM.2008.019, March 2008

Publication History:
Published Online:


Background: Cord artery protein S-100 levels at birth are potential markers of brain damage after asphyxia. Our aim was to investigate if S-100 levels were elevated in neonates with indirect signs of asphyxia during birth. S-100 levels in cord blood were studied in relation to cardiotocography (CTG) and fetal electrocardiography (FECG) changes during birth and to acidemia in umbilical blood.

Material and methods: This case-control study was performed in parallel to a large randomized controlled trial (RCT) studying FECG at birth. Protein S-100 samples were collected from 103 neonates at birth and related to the CTG and ECG changes during labor and to pH in umbilical blood.

Results: Protein S-100 was significantly higher in neonates with umbilical artery blood pH≤7.05, compared to neonates with pH>7.05. Furthermore, neonates with preterminal CTG patterns showed increased S-100 levels compared to neonates with normal CTG. Neonates having significant CTG and ECG changes, leading to intervention according to clinical guidelines, showed significantly higher S-100 levels compared to neonates without such indication of intervention.

Conclusion: A relation exists between S-100 in umbilical blood at birth, acidosis and pathological patterns in CTG and FECG during labor.

Keywords: Acidemia; asphyxia; brain damage marker; CTG; ECG; fetal monitoring; protein S-100

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