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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, M.J.M.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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Detection of feto-maternal infection/inflammation by the soluble receptor for advanced glycation end products (sRAGE): results of a pilot study

Zdeněk Hájek1 / Anna Germanová2 / Michal Koucký3 / Tomáš Zima4 / Pavel Kopecký5 / Marie Vítkova6 / Antonín Pařízek7 / Marta Kalousová8

1 Department of Obstetrics and Gynecology, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

2 Institute of Clinical Chemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

3 Department of Obstetrics and Gynecology, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

4 Institute of Clinical Chemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

5 Department of Obstetrics and Gynecology, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

6 Department of Pathology, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

7 Department of Obstetrics and Gynecology, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

8 Institute of Clinical Chemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

Corresponding author: Zdeněk Hájek, MD, PhD Department of Obstetrics and Gynecology 1st Faculty of Medicine and General University Hospital Charles University Apolinářska 18 128 51 Prague 2 Czech Republic Tel.: +420 224967414 Fax: +420 224922545

Citation Information: Journal of Perinatal Medicine. Volume 36, Issue 5, Pages 399–404, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: 10.1515/JPM.2008.080, September 2008

Publication History

Received:
2008-02-14
Revised:
2008-05-02
Accepted:
2008-05-26
Published Online:
2008-09-05

Abstract

Objective: The receptor for advanced glycation end products, RAGE, plays an important role in the pathogenesis of several diseases. sRAGE, soluble receptor for advanced glycation end products, is an inhibitor of the pathological effect mediated via RAGE. The aim of this study was to assess the usefulness of measuring sRAGE concentration in pregnant women with threatening preterm labor.

Methods: Serum levels of sRAGE, interleukin-6 (IL-6) and routine markers of inflammation were determined in 46 pregnant women with threatening preterm labor, 35 healthy pregnant women and 15 non-pregnant controls.

Results: Serum levels of sRAGE in healthy pregnant women were significantly lower than in non-pregnant controls (669±296 vs. 1929±727 pg/mL, P<0.05). Women with threatening preterm birth had a significantly higher concentration of serum sRAGE in comparison with healthy pregnant women (819±329 pg/mL vs. 669±296 pg/mL, P<0.05). Conversely, patients with PPROM had significantly lower levels of sRAGE compared with patients with threatening premature labor (600±324 pg/mL, P<0.05). sRAGE correlated negatively with leukocyte counts (r=−0.325, P<0.05).

Conclusions: sRAGE might be a new and promising marker of premature labor, especially with the symptoms of PPROM.

Keywords: Fetal inflammation; PPROM; preterm labor; soluble receptor for advanced glycation end products; sRAGE

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