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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, M.J.M.C. / Kurjak M.D., Asim / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

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Maternal serum adiponectin multimers in patients with a small-for-gestational-age newborn

Shali Mazaki-Tovi1, 2 / Roberto Romero1, 3 / Edi Vaisbuch1, 2 / Offer Erez1, 2 / Pooja Mittal1, 2 / Tinnakorn Chaiworapongsa1, 2 / Sun Kwon Kim1 / Percy Pacora1 / Lami Yeo1, 2 / Francesca Gotsch1 / Zhong Dong1 / Bo Hyun Yoon4 / Sonia S. Hassan1, 2 / Juan Pedro Kusanovic1, 2

1Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, and Detroit, MI, USA

2Department of Obstetrics and Gynecology, Wayne State University/Hutzel Women's Hospital, Detroit, MI, USA

3Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA

4Department of Obstetrics and Gynecology, Seoul National University, Seoul, Korea

Corresponding author: Roberto Romero, MD Perinatology Research Branch Intramural Division NICHD/NIH/ DHHS Hutzel Women's Hospital-Box No. 4 3990 John R Detroit MI 48201 USA Tel.: +1-(313) 993-2700 Fax: +1-(313) 993-2694

Citation Information: Journal of Perinatal Medicine. Volume 37, Issue 6, Pages 623–635, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: 10.1515/JPM.2009.128, June 2009

Publication History

Received:
2008-12-31
Revised:
2009-04-01
Accepted:
2009-05-04
Published Online:
2009-06-17

Abstract

Objective: Several mechanisms of disease have been implicated in the pathophysiology of small-for-gestational-age (SGA) including an anti-angiogenic state, and an exaggerated intravascular pro-inflammatory response. Adiponectin plays a role in a wide range of biological activities including those that have been implicated in the pathophysiology SGA. Thus, the aim of this study was to determine if third trimester adiponectin concentrations differed between women with normal weight infants and those with an SGA neonate.

Study design: This cross-sectional study included women with: 1) a normal pregnancy (n=234); and 2) an SGA neonate (n=78). SGA was defined as a birth weight below the 10th percentile for gestational age at birth. The study population was further stratified by first trimester body mass index (BMI) (normal weight <25 kg/m2 vs. overweight/obese ≥25 kg/m2). Maternal serum adiponectin multimers [total, high-molecular-weight (HMW), medium-molecular-weight (MMW) and low-molecular-weight (LMW)] concentrations were determined by ELISA. Non-parametric statistics were used for analyses.

Results: 1) The median maternal serum concentrations of total, HMW and MMW adiponectin were significantly lower in patients with an SGA neonate than in those with normal pregnancies; 2) patients with an SGA neonate had a significantly lower median HMW/total adiponectin ratio and higher median MMW/total adiponectin and LMW/total adiponectin ratios than those with a normal pregnancy; 3) among patients with an SGA neonate, neither maternal serum concentrations of adiponectin multimers, nor their relative distribution differ between normal weight and overweight/obese patients.

Conclusion: 1) Pregnancies complicated by an SGA neonate are characterized by a alterations in the maternal serum adiponectin multimers concentrations and their relative abundance; 2) the findings reported herein suggest that maternal adipose tissue may play a role, in the pathogenesis of SGA.

Keywords: Adipokines; adipose tissue; body mass index (BMI); fetal growth; high-molecular-weight (HMW) adiponectin; low-molecular-weight (LMW) adiponectin; medium-molecular-weight (MMW) adiponectin; obesity; overweight; pregnancy; small-for-gestational-age (SGA)

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