Jump to ContentJump to Main Navigation

Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, M.J.M.C. / Kurjak M.D., Asim / Lee, Ben H. / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Ogata, Edward / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

7 Issues per year

IMPACT FACTOR 2014: 1.358
5-year IMPACT FACTOR: 1.597

SCImago Journal Rank (SJR) 2014: 0.731
Source Normalized Impact per Paper (SNIP) 2014: 0.687
Impact per Publication (IPP) 2014: 1.483



Retinol binding protein 4 – a novel association with early-onset preeclampsia

Edi Vaisbuch1, 2 / Roberto Romero1, 2, 3 / Shali Mazaki-Tovi1, 2 / Offer Erez1, 2 / Sun Kwon Kim1 / Tinnakorn Chaiworapongsa1, 2 / Francesca Gotsch1 / Nandor Gabor Than1 / Zhong Dong1 / Percy Pacora1 / Ronald Lamont1, 2 / Lami Yeo1, 2 / Sonia S. Hassan1, 2 / Juan Pedro Kusanovic1, 2

1Intramural Division, Perinatology Research Branch, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, and Detroit, MI, USA

2Department of Obstetrics and Gynecology, Wayne State University/Hutzel Women's Hospital, Detroit, MI, USA

3Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA

Corresponding author: Roberto Romero, MD Intramural Division, Perinatology Research Branch NICHD/NIH/DHHS, Hutzel Women's Hospital-Box No. 4 3990 John R Detroit MI 48201 USA Tel.: +1 (313) 993-2700 Fax: +1 (313) 993-2694

Citation Information: Journal of Perinatal Medicine. Volume 38, Issue 2, Pages 129–139, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: 10.1515/jpm.2009.140, August 2009

Publication History

Published Online:


Objective: Dysregulation of maternal circulating adipokines has been implicated in several “great obstetrical syndromes” including preeclampsia (PE), small-for-gestational age (SGA) neonate and fetal death (FD). It has been suggested that adipokines provide a molecular link between metabolic derangements and inflammatory response in complicated pregnancies. Retinol binding protein 4 (RBP4), a novel adipokine, plays a role in obesity-related disorders, as well as in the regulation of the immune response. The aim of this study was to determine whether there are changes in maternal plasma concentrations of RBP4 in patients with PE and in those with an SGA neonate or FD.

Study design: This cross-sectional study included patients in the following groups: 1) normal pregnancy (n=134); 2) PE (n=104); 3) SGA neonate (n=28); and 4) FD (n=37). Maternal plasma RBP4 concentrations were determined by ELISA. Non-parametric statistics were used for analysis.

Results: 1) The median maternal plasma RBP4 concentration was higher among patients with PE than in those with a normal pregnancy (P=0.03); 2) The median maternal plasma RBP4 concentrations of patients with preterm PE (<37 weeks) was higher than that of those with term PE (P=0.017) and than that of those with a normal pregnancy (P=0.002); 3) The median maternal plasma RBP4 concentration did not differ significantly between patients with a normal pregnancy and those with an SGA neonate or with an FD; 4) Among normal pregnant women, the maternal plasma RBP4 concentrations did not correlate with pre-pregnancy body mass index, gestational age at blood sampling and neonatal birthweight.

Conclusions: 1) Preeclampsia, but not pregnancy with an SGA neonate or an FD, is associated with a higher median maternal plasma concentration of RBP4 than normal pregnancy; 2) Preterm PE, and specifically early-onset PE, is associated with higher median RBP4 concentrations in maternal plasma compared to term PE. These findings suggest a role for RBP4 in the pathogenesis of preterm PE, but not in SGA and FD.

Keywords: Adipokines; fetal death (FD); fetal demise; intrauterine fetal death (IUFD); pregnancy; RBP4; small-for-gestational age (SGA) neonate

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Surabhi Nanda, George Nikoletakis, Desislava Markova, Leona C.Y. Poon, and Kypros H. Nicolaides
Metabolism, 2013, Volume 62, Number 6, Page 814
Arrigo Fruscalzo, Anna Biasioli, Ambrogio P Londero, Maria Ceraudo, Giuliana Stel, Serena Bertozzi, Diego Marchesoni, Lorenza Driul, and Francesco Curcio
Gynecological Endocrinology, 2013, Volume 29, Number 4, Page 323
Dejene F. Abetew, Chunfang Qiu, Neway G. Fida, Michal Dishi, Karin Hevner, Michelle A. Williams, and Daniel A. Enquobahrie
Diabetes Research and Clinical Practice, 2013, Volume 99, Number 1, Page 48
Shali Mazaki-Tovi, Michal Kasher-Meron, Rina Hemi, Jigal Haas, Itai Gat, Daniel Lantsberg, Israel Hendler, and Hannah Kanety
American Journal of Obstetrics and Gynecology, 2012, Volume 207, Number 5, Page 412.e1
Eleazar Soto, Roberto Romero, Juan Pedro Kusanovic, Giovanna Ogge, Youssef Hussein, Lami Yeo, Sonia S Hassan, Chong Jai Kim, and Tinnakorn Chaiworapongsa
Journal of Maternal-Fetal and Neonatal Medicine, 2012, Volume 25, Number 5, Page 498
Giovanna Ogge, Tinnakorn Chaiworapongsa, Roberto Romero, Youssef Hussein, Juan Pedro Kusanovic, Lami Yeo, Chong Jai Kim, and Sonia S. Hassan
Journal of Perinatal Medicine, 2011, Volume 39, Number 6
K.J. Ahn, E.A. Choi, J. Kim, J.H. Lee, K.H. Lee, D. Bang, and S.B. Cho
British Journal of Dermatology, 2011, Volume 165, Number 4, Page 837
Te-Fu Chan, Yung-Chieh Tsai, Chen-Hsuan Wu, Chien-Hung Lee, Shih-Han Wang, and Juin-Huang Su
Gynecologic and Obstetric Investigation, 2011, Volume 72, Number 2, Page 98
Weerapan Khovidhunkit, Promphan Pruksakorn, Wanee Plengpanich, and Thipaporn Tharavanij
Metabolism, 2012, Volume 61, Number 1, Page 65
Pooja Mittal, Roberto Romero, Adi L. Tarca, Sorin Draghici, Chia-Ling Nhan-Chang, Tinnakorn Chaiworapongsa, John Hotra, Ricardo Gomez, Juan Pedro Kusanovic, Deug-Chan Lee, Chong Jai Kim, and Sonia S. Hassan
American Journal of Obstetrics and Gynecology, 2011, Volume 204, Number 2, Page 177.e15
Hyun-Joo Seol, Jae-Won Kim, and Hai-Joong Kim
Journal of Perinatal Medicine, 2011, Volume 39, Number 3
Daniel B. DiGiulio, MariaTeresa Gervasi, Roberto Romero, Shali Mazaki-Tovi, Edi Vaisbuch, Juan Pedro Kusanovic, Kimberley S. Seok, Ricardo Gómez, Pooja Mittal, Francesca Gotsch, Tinnakorn Chaiworapongsa, Enrique Oyarzún, Chong Jai Kim, and David A. Relman
Journal of Perinatal Medicine, 2010, Volume 38, Number 5

Comments (0)

Please log in or register to comment.