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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / D'Alton, MD, Mary E. / Dimitrou, G. / Grunebaum, Amos / Hentschel, Roland / Köpcke, W. / Kawabata, Ichiro / Keirse, M.J.M.C. / Kurjak M.D., Asim / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Romero, Roberto / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Seri, Istvan / Vetter, Klaus / Winn, Hung N. / Young, Bruce K. / Zimmermann, Roland

6 Issues per year

IMPACT FACTOR 2013: 1.425

SCImago Journal Rank (SJR): 0.782
Source Normalized Impact per Paper (SNIP): 0.928



Early protective effect of hypothermia in newborn pigs after hyperoxic, but not after normoxic, reoxygenation

Marit L. Dalen1 / Tomas N. Alme1 / Berit H. Munkeby1 / Else Marit Løberg2 / Are Hugo Pripp3 / Tom Eirik Mollnes4 / Terje Rootwelt5 / Ola Didrik Saugstad1

1Department of Paediatric Research and Institute for Surgical Research, University of Oslo and Oslo University Hospital, Rikshospitalet, Oslo, Norway

2Department of Pathology, Oslo University Hospital, Ullevål, Oslo, Norway

3Biostatistics Unit, Department of Research Services, Oslo University Hospital, Rikshospitalet, Oslo, Norway

4Institute of Immunology, University of Oslo and Oslo University Hospital, Rikshospitalet, Oslo, Norway

5Women and Children's Clinic, Oslo University Hospital, Rikshospitalet, Oslo, Norway

Corresponding author: Marit Lunde Dalen Department of Paediatric Research Oslo University Hospital, Rikshospitalet N-0027 Oslo Norway Tel.: +47 23072495 Fax: +47 23072780

Citation Information: Journal of Perinatal Medicine. Volume 38, Issue 5, Pages 545–556, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: 10.1515/jpm.2010.081, July 2010

Publication History

Published Online:


Mild hypothermia can attenuate the development of brain damage after asphyxia. Supplemental oxygen during resuscitation increases generation of reactive oxygen species, compared to room air. It is unknown if supplemental oxygen affects hypothermic neuroprotection. We studied the early effects of hyperoxic reoxygenation and subsequent hypothermia on tissue oxygenation, microcirculation, inflammation and brain damage after global hypoxia. Anesthetized newborn pigs were randomized to control (n=6), or severe global hypoxia (n=46). Three pigs died during hypoxia or reoxygenation. After 20-min reoxygenation with room air (n=22) or 100% oxygen (n=21), pigs were randomized to normothermia (deep rectal temperature 39°C, n=22) or total body cooling (35°C, n=21) for 6.5 h before the experiment was terminated. We demonstrated a differential effect of post-hypoxic hypothermia between animals reoxygenated with 100% oxygen and with room air, with reduced damage only in hypothermic animals reoxygenated with 100% oxygen (P=0.001). Hyperoxic reoxygenation resulted in a significant overshoot in striatal oxygen tension, without affecting microcirculation. Inflammatory response after the insult did not differ between groups. The results indicate an early protective effect of hypothermia which may vary with oxygen level used during reoxygenation.

Keywords: Hyperoxia; hypothermia; hypoxia; inflammation; neuroprotection; newborn

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