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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

Editorial Board Member: / Bancalari, Eduardo / Greenough, Anne / Genc, Mehmet R. / Chervenak, Frank A. / Chappelle, Joseph / Aslam, Muhammad / Bergmann, Renate L. / Bernardes, J.F. / Bevilacqua, G. / Blickstein, Isaac / Cabero Roura, Luis / Carbonell-Estrany, Xavier / Carrera, Jose M. / D`Addario, Vincenzo / Dimitrou, G. / Grunebaum, G. E. / Harding, Jane / Hentschel, Roland / Kawabata, Ichiro / Keirse, M.J.M.C. / Kurjak M.D., Asim / Levene, Malcolm / Lockwood, Charles J. / Marsal, Karel / Makatsariya, Alexander / Nishida, Hiroshi / Papp, Zoltán / Pejaver, Ranjan Kumar / Pooh, Ritsuko K. / Saugstad, Ola D. / Schenker, Joseph G. / Sen, Cihat / Geijn, Herman P. / Vetter, Klaus / Young, Bruce K. / Zimmermann, Roland / Köpcke, W.

6 Issues per year

Increased IMPACT FACTOR 2012: 1.949
Rank 29 out of 77 in category Obstretics & Gynecology and 39 out of 121 in category Pediatrics in the 2012 Thomson Reuters Journal Citation Report/Science Edition

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Does very advanced maternal age, with or without egg donation, really increase obstetric risk in a large tertiary center?

Alon Shrim1 / Ishai Levin2 / Angela Mallozzi1 / Richard Brown1 / Kareima Salama1 / Ronni Gamzu2 / Benny Almog1

1Department of Obstetrics and Gynaecology, McGill University, Royal Victoria Hospital, Montreal, QC, Canada

2Department of Gynecology, Lis Maternity Hospital, Tel-Aviv Sourasky Medical Centre affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel

Corresponding author: Alon Shrim, MD Department of Obstetrics and Gynecology McGill University 687 Pine Avenue West Montreal Quebec H3A 1A1 Canada Tel.: +514-934-1934 ext. 34280 Fax: +1 514 843 1448

Citation Information: Journal of Perinatal Medicine. Volume 38, Issue 6, Pages 645–650, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: 10.1515/jpm.2010.084, August 2010

Publication History:
Received:
2010-03-25
Revised:
2010-04-23
Accepted:
2010-04-26
Published Online:
2010-08-13

Abstract

Objective: To assess complications of very advanced maternal age (VAMA) pregnancies ≥45 years with and without egg donation (ED).

Study design: Obstetric and neonatal complications were studied in 20,659 singleton pregnancies according to three maternal age groups: 20–39, 40–44 [advanced maternal age (AMA)] and ≥45 years (VAMA). Twenty pregnancies within the AMA/LAMA group that were achieved with ED were compared with age-matched controls.

Results: AMA mothers were more likely to have higher rates of preterm deliveries (OR 1.25), cesarean sections (OR 1.84) hypertension (OR 1.71) and diabetes (OR 2.45). Their newborns were more frequently small for gestational age (OR 1.30), and were more likely to have high rates of respiratory distress syndrome (OR 1.66), neonatal intensive care admission (OR 1.40) and perinatal/neonatal mortality (OR 1.83). VAMA pregnancies had >50% cesarean section rate and a high rate of diabetes (OR 2.29), hypertension (OR 1.54) and postpartum hemorrhage (OR 5.38). Congenital anomalies were more common among ED pregnancies.

Conclusions: The higher rate of pregnancy complications for women ≥40 years is not further increased after 45 years of age.

Keywords: Advanced maternal age; late maternal age; pregnancy complications

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