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Journal of Perinatal Medicine

Official Journal of the World Association of Perinatal Medicine

Editor-in-Chief: Dudenhausen, Joachim W.

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Amniotic lamellar body counts can predict the occurrence of respiratory distress syndrome as well as transient tachypnea of the newborn (TTN)

1, 3 / Yuichiro Takahashi3 / Shigenori Iwagaki3 / Yasushi Uchida4 / Ichiro Kawabata3 / Masahiro Hayakawa2 / Seiji Sumigama1 / Hiromi Hayakawa1 / Tomomi Kotani1 / Fumitaka Kikkawa1

1Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan

2Department of Pediatrics, Nagoya University School of Medicine, Nagoya, Japan

3Department of Fetal and Maternal Medicine, Nagara Medical Center, Gifu City, Japan

4Department of Pediatrics, Nagara Medical Center, Gifu City, Japan

Corresponding author: Hiroyuki Tsuda, MD Department of Obstetrics and Gynecology Nagoya University School of Medicine 65 Tsurumai-cho Showa-ku Nagoya 466-8550 Japan Tel./Fax: +81-52-744-2261

Citation Information: Journal of Perinatal Medicine. Volume 39, Issue 3, Pages 245–250, ISSN (Online) 1619-3997, ISSN (Print) 0300-5577, DOI: 10.1515/jpm.2011.006, February 2011

Publication History

Received:
2010-07-19
Revised:
2010-10-02
Accepted:
2010-10-21
Published Online:
2011-02-11

Abstract

Aims: The purpose of this study is to predict the occurrence of transient tachypnea of the newborn (TTN) using amniotic lamellar body count (LBC) and compare the LBCs in neonates with TTN with the LBCs in neonates with respiratory distress syndrome (RDS) and controls.

Methods: Three hundred and eighty-one amniotic fluid samples were obtained at cesarean section from 27 to 40 weeks of gestation. Samples were analyzed immediately without centrifugation and the number of lamellar bodies was counted.

Results: The LBC in amniotic fluid ranged from 1,000 to 577,000/μL. An LBC cut-off value of 48,500/μL resulted in 84.7% sensitivity, 76.2% specificity, and 98.1% negative predictive value for predicting TTN. The LBC in neonates with TTN was significantly lower than that in controls (50,000 vs. 122,000; P<0.001) and significantly higher than that in neonates with RDS (50,000 vs. 21,000; P=0.042).

Conclusions: We established a cut-off value of LBC for predicting the occurrence of TTN. The LBC in neonates with TTN was significantly lower than that in controls. Amniotic LBC can be a useful marker to predict if neonatal respiratory management is required.

Keywords: Amniotic fluid; cesarean section; lamellar body; respiratory distress syndrome; transient tachypnea of the newborn

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[1]
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[2]
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[3]
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[4]
Hiroyuki Tsuda, Tomomi Kotani, Seiji Sumigama, Yukio Mano, Li Hua, Hiromi Hayakawa, Masahiro Hayakawa, Yoshiaki Sato, and Fumitaka Kikkawa
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