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LaboratoriumsMedizin

Offizielles Organ der Deutschen Vereinten Gesellschaft für Klinische Chemie und Laboratoriumsmedizin e.V. (DGKL) und affiliiert mit der Österreichischen Gesellschaft für Laboratoriumsmedizin und Klinische Chemie (ÖGLMKC)

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Reference values for thyroid function tests during pregnancy1

Christin Spielhagen1 / Katja Bobermien2 / Alexander Krebs3 / Henri Wallaschofski4

1Klinik und Poliklinik für Innere Medizin A (Department of Internal Medicine A, Endocrinolgy), Universität Greifswald, Germany

2Klinik und Poliklinik für Frauenheilkunde und Geburtsmedizin (Department of Gynecology and Obstetrics), Universität Greifswald, Germany

3Institut für Klinische Chemie und Laboratoriumsmedizin (Institute for Clinical Chemistry and Laboratory Medicine), Universität Greifswald, Germany

4Klinik und Poliklinik für Innere Medizin A (Department of Internal Medicine A, Endocrinolgy), Universität Greifswald, Germany

Correspondence: Christin Spielhagen, Klinik und Poliklinik für Innere Medizin A, Ernst-Moritz-Arndt-Universität Greifswald, Friedrich-Loeffler-Strasse 23a, D-17475 Greifswald, Germany Tel.: +49-(03834)-86-6661 Fax: +49-(03834)-86-6662

Citation Information: LaboratoriumsMedizin. Volume 33, Issue 1, Pages -–-, ISSN (Online) 1439-0477, ISSN (Print) 0342-3026, DOI: 10.1515/JLM.2009.004et, February 2009

Publication History

Published Online:
2009-02-09

Abstract

Euthyroid women experience dramatic changes in the demand for thyroid hormone production as early as the first trimester of pregnancy. These adaptations are important for fetal neurodevelopment and organ development as well as maternal health and successful full-term pregnancy. Thyroid disease is the most common endocrine condition in women of childbearing age and leads to complications in approximately 1–2% of all pregnancies. The hypermetabolic state of normal pregnancy makes clinical assessment of thyroid function more difficult and therefore thyroid function often needs to be investigated biochemically. However, physiological changes of pregnancy, including a 50% plasma volume expansion, increased thyroid binding globulin production, and a relative iodine deficiency, implicate that thyroid hormone reference ranges for non-pregnant women may not be appropriate in pregnancy. Therefore, gestation-specific reference intervals assist in appropriate clinical management of thyroid disease in pregnancy to ensure maternal and fetal health.

Keywords: pregnancy; reference intervals; thyroid disease; thyroid function

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