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Immunosuppressant drug monitoring – a routine undertaking?1

Christoph Seger1 / Michael Vogeser12

1Institute of Medical and Chemical Laboratory Diagnostics (ZIMCL), University Hospital Innsbruck, Innsbruck, Austria

2Institute of Clinical Chemistry, Hospital of the University of Munich, Munich, Germany

Correspondence: Christoph Seger, PhD, Institute of Medical and Chemical Laboratory Diagnostics (ZIMCL), University Hospital Innsbruck, Innsbruck, Austria Tel.: +43 51250481155 Fax: +43 51250424088

Citation Information: LaboratoriumsMedizin. Volume 34, Issue 3, Pages -–-, ISSN (Online) 1439-0477, ISSN (Print) 0342-3026, DOI: 10.1515/jlm.2010.027et, July 2010

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The quantitative assessment of immunosuppressant drug levels is still one of the most challenging therapeutic drug monitoring procedures in clinical routine. During the past years, several technical developments matured to usable methods. In addition to immunoassays, liquid chromatography-tandem mass spectrometry has become a key method in immunosuppressant therapeutic drug monitoring. This overview should aid in understanding the advantages and disadvantages of the various assays and methods. UK-NEQAS proficiency testing results are used for an inter-assay comparison approach.

Keywords: immunoassays; immunosuppressant drugs; liquid chromatography-tandem mass spectrometry (LC-MS/MS); proficiency testing; tandem mass spectrometry; therapeutic drug monitoring

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