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LaboratoriumsMedizin

Offizielles Organ der Deutschen Vereinten Gesellschaft für Klinische Chemie und Laboratoriumsmedizin e.V. (DGKL) und affiliiert mit der Österreichischen Gesellschaft für Laboratoriumsmedizin und Klinische Chemie (ÖGLMKC)

Editor-in-Chief: Schuff-Werner, Peter

Editorial Board Member: Ahmad-Nejad, Parviz / Bidlingmaier, Martin / Karsten, Conrad / Fraunberger, Peter / Ghebremedhin, Beniam / Kiehntopf, Michael / Klein, Hanns-Georg / Klouche, Mariam / Kohse, Klaus P. / Kratzsch, Jürgen / Luppa, Peter B. / März, Winfried / Nebe, Carl Thomas / Orth, Matthias / Ruf, Andreas / Steimer, Werner / Stieber, Petra / Weber, Bernard / Wieland, Eberhard / Sack, Ulrich / Tumani, Hayrettin / Zettl, Uwe K.


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Challenges in the measurement of serum testosterone concentrations as a biomarker of men's health1

1 / Christin Spielhagen1 / Matthias Nauck1

1Institute for Clinical Chemistry and Laboratory Medicine, University of Greifswald, Greifswald, Germany

Korrespondenz: Dr. rer. med. Robin Haring, Institut für Klinische Chemie und Laboratoriumsmedizin, Ernst-Moritz-Arndt-Universität Greifswald, Ferdinand-Sauerbruch-Straße, 17475 Greifswald. Telefon: +49-3834-8619656, Fax: +49-3834-865502

Citation Information: LaboratoriumsMedizin. Volume 35, Issue 1, Pages -–-, ISSN (Online) 1439-0477, ISSN (Print) 0342-3026, DOI: 10.1515/JLM.2011.001_engl, April 2011

Publication History

Published Online:
2011-04-05

Abstract

Male testosterone concentrations gained recent attention in the field of andrology. Various epidemiological cohort studies presented associations of low serum testosterone concentrations with incident cardiovascular risk factors and increased mortality risk. Furthermore, low serum testosterone concentrations are integral part for the diagnosis of late-onset hypogonadism. Because of their high validity and throughput, mass spectrometry assays have replaced conventional immunoassays for testosterone measurement, and are believed to become the "gold standard" for sex hormone quantitation. This article will focus on challenges in the measurement of serum testosterone concentrations and will provide practical information on the interpretation of serum testosterone measurements.

Keywords:: androgens; biomarker; immunoassay; mass spectrometry; testosterone

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