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formerly Central European Journal of Medicine

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Wheezing and lung function measured in subjects exposed to various levels of fine particles and polycyclic aromatic hydrocarbons

1Chair of Epidemiology and Preventive Medicine, Coll. Med. Jagiellonian University in Krakow, Krakow, Poland

2Columbia Center for Children’s Environmental Health Mailman School Public Health, Columbia University, NY, USA

3Harvard School of Public Health, Harvard University, Boston, MA, USA

4Department of Analytical and Environmental Chemistry, Southwest Research Institute, San Antonio, Texas, USA

© 2007 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. (CC BY-NC-ND 3.0)

Citation Information: Open Medicine. Volume 2, Issue 1, Pages 66–78, ISSN (Online) 2391-5463, DOI: 10.2478/s11536-006-0043-6, March 2007

Publication History

Published Online:
2007-03-01

Abstract

The main purpose of the study was to assess the occurrence of wheezing and lung function in non-smoking women exposed to various levels of fine particulate matter(FP) and polycyclic aromatic hydrocarbons (PAH). Out of the total study group, 152 women were included in the lower exposed group (PM2.5 ≤34.3μg/m3 or PAHs ≤ 22.9ng/ m3) and 96 persons in higher concentrations of both air pollutants (PM2.5>34.3μg/m3 and PAHs > 22.9ng/ m3). Except for FVC and FEV1, all lung forced ventilatory flows (PEFR, FEF25% FEF50%, FEF75%, FEF25−75%) were significantly lower in the higher exposed group. The findings suggest bronchoconstriction within the respiratory tract, which may be related to the exposure under study. This was consistent with a higher prevalence of wheezing in more exposed subjects. It was shown that higher levels of both pollutants increased the risk of wheezing by factor 5.6 (95% CI: 1.77–17.8) after accounting for potential confounders such as allergic diseases and exposure to ETS. This study suggests that pollutants in question may have the capacity to promote broncho-constriction and asthmatic symptoms, possibly by bronchial inflammation resulting from the exposure.

Keywords: Personal exposure; fine particles; polycyclic aromatic hydrocarbons; lung function; wheezing

  • [1] J.G. Ayres: “Chronic effects of air pollution [editorial]”, Occup. Environ. Med., Vol. 59, (2002), pp. 147–148. http://dx.doi.org/10.1136/oem.59.3.147 [CrossRef]

  • [2] H.R. Anderson, C. Spix, S. Medina, J.P. Schouten, J. Castellsague, G. Rossi, D. Zmirou, G. Touloumi, B. Wojtyniak, A. Ponka, L. Bacharova, J. Schwartz and K. Katsouyanni: “Air pollution and daily admissions for chronic obstructive pulmonary disease in 6 European cities: results from the APHEA project”, Eur. Respir. J., Vol. 10, (1997), pp. 1064–1071. http://dx.doi.org/10.1183/09031936.97.10051064 [CrossRef]

  • [3] R.W. Atkinson, H.R. Anderson, J. Sunyer, J. Ayres, M. Baccini, J.M. Vonk, A. Boumghar, F. Forastiere, B. Forsberg, G. Touloumi, J. Schwartz and K. Katsouyanni: “Acute effects of particulate air pollution on respiratory admissions: results from APHEA 2 project”, Am. J. Respir. Crit. Care Med., Vol. 164, (2001), pp. 1860–1866.

  • [4] I. Baldi, J.F. Tessier, F. Kauffmann, H. Jacqmin-Gadda, C. Nejjari and R. Salamon: “Prevalence of asthma and mean levels of air pollution: results from the French PAARC survey”, Eur. Respir. J., Vol. 14, (1999), pp. 132–138. http://dx.doi.org/10.1034/j.1399-3003.1999.14a22.x [CrossRef]

  • [5] W.L. Beeson, D.E. Abbey and S.F. Knutsen: ”Long-term concentrations of ambient air pollutants and incident lung cancer in California adults: results from the AHSMOG study”, Environ. Health Perspect., Vol. 106, (1998), pp. 813–823.

  • [6] R.J. Delfino, A.M. Murphy-Moulton, R.T. Burnett, J.R. Brook and M.R. Becklake: “Effects of air pollution on emergency room visits for respiratory illnesses in Montreal, Quebec”, Am. J. Respir. Crit. Care Med., Vol. 155, (1997), pp. 568–576.

  • [7] D.W. Dockery, J. Schwartz and J.D. Spengler: “Air pollution and daily mortality: associations with particulates and acid aerosols”, Environ. Res., Vol. 59, (1992), pp. 362–373. http://dx.doi.org/10.1016/S0013-9351(05)80042-8 [CrossRef]

  • [8] D.W. Dockery and C.A. Pope: ”Acute respiratory effects of particulate air pollution”, Ann. Rev. Public Hlth., Vol. 15, (1994), pp. 107–132. http://dx.doi.org/10.1146/annurev.pu.15.050194.000543 [CrossRef]

  • [9] D.W. Dockery, J. Cunningham, A.I. Damokosh., L.M. Neas, J.D. Spengler, P. Koutrakis, J.H. Ware, M. Raizenne and F.E. Speizer: “Health effects of acid aerosols on North American children: respiratory symptoms”, Environ. Health Perspect., Vol. 104, (1996), pp. 500–505.

  • [10] W. Jedrychowski and E. Flak: “Effects of air quality on chronic respiratory symptoms adjusted for allergy among preadolescent children”, Eur. Respir. J., Vol. 11, (1998), pp. 1312–1318. http://dx.doi.org/10.1183/09031936.98.11061312 [CrossRef]

  • [11] K.L. Timonen and J. Pekkanen: “Air pollution and respiratory health among children with asthmatic or cough symptoms”, Am. J. Respir. Crit. Care Med., Vol. 156, (1997), pp. 546–552.

  • [12] D.E. Abbey, R.J. Burchette, S.F. Knutsen, W.F. McDonnell, M.D. Lebowitz and P. Enright: “Long-term particulate and other air pollutants and lung function in non-smokers”, Am. J. Respir. Crit. Care Med., Vol. 158, (1998), pp. 289–298.

  • [13] D.J. Berglund, D.E. Abbe, M.D. Lebowitz, S.F. Knutsen and W.F. McDonnell: “Respiratory symptoms and pulmonary function in an elderly non-smoking population”, Chest, Vol. 115, (1999), pp. 49–59. http://dx.doi.org/10.1378/chest.115.1.49 [CrossRef]

  • [14] B. Brunekreft, P.I. Kinney, J.H. Ware, D.W. Dockery, F.E. Speizer, J.D. Spengler and B.G. Ferris: “Sensitive subgroups and normal variation in pulmonary function response to air pollution episodes”, Environ. Health Perspect., Vol. 90, (1991), pp. 189–193.

  • [15] W. Jedrychowski, E., Flak and E. Mróz: ”The adverse effect of low levels of ambient air pollutants on lung function growth in preadolescent children”, Environ. Health Perspect., Vol. 107, (1999), pp. 669–674.

  • [16] D.E. Abbey, N. Nishino, W.F. McDonnell, R.J. Burchette, S.F. Knutsen, W.L. Beeson and J.X. Yang: “Long-term inhalable particles and other air pollutants related to mortality in nonsmokers”, Am. J. Respir. Crit. Care Med., Vol. 159, (1999), pp. 373–382.

  • [17] F. Barbone, M. Bovenzi, F. Cavalleri, G. Stanta: “Air pollution and lung cancer in Trieste, Italy”, Am. J. Epidemiol., Vol. 141, (1995), pp. 1161–1169.

  • [18] A.J. Cohen and C.A. Pope: “Lung cancer and air pollution”, Environ. Health Perspect., Vol. 103, Suppl. 8, (1995), pp. 219–224.

  • [19] D.W. Dockery, C.A. Pope, X. Xu, J.D. Spengler, J.H. Ware, M.E. Fay, B.G. Ferris and F.E. Jr Speizer: “An association between air pollution and mortality in six U.S. cities”, N. Engl. J. Med., Vol. 329, (1993), pp. 1753–1759. http://dx.doi.org/10.1056/NEJM199312093292401 [CrossRef]

  • [20] F. Dominici, M. Daniels, S.L. Zeger and J.M. Samet: “Air pollution and mortality: estimating regional and national dose-response relationships”, J. Am. Stat. Assoc., Vol. 97, (2002), pp. 100–111. http://dx.doi.org/10.1198/016214502753479266 [CrossRef]

  • [21] W. Jedrychowski, H. Becher, J. Wahrendorf and Z. A. Basa-Cierpialek: “Case-control study of lung cancer with special reference to the effect of air pollution in Poland”, J. Epidemiol. Commun. Health, Vol. 44, (1990), pp. 114–120.

  • [22] K. Katsouyanni, A. Karakatsani, I. Messari, G. Touloumi, A. Hatzakis, A. Kalandidi and D. Trichopoulos: “Air pollution and cause specific mortality in Athens”, J. Epidemiol. Community Health, Vol. 44, (1990), pp. 321–324. http://dx.doi.org/10.1136/jech.44.4.321 [CrossRef]

  • [23] F. Laden, L.M. Neas, D.W. Dockery and J. Schwartz: “Association of fine particulate matter from different sources with daily mortality in six U.S. cities”, Environ. Health Perspect., Vol. 108, (2000), pp. 941–947.

  • [24] C.A. Pope, R.T. Burnett, M.J. Thun, E.E. Calle, D. Krewski, K. Ito and G.D. Thurston: “Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution”, J. Am. Med. Assoc., Vol. 287, (2002), pp. 1132–1141. http://dx.doi.org/10.1001/jama.287.9.1132 [CrossRef]

  • [25] J.M. Samet, F. Dominici, F.C. Curriero, I. Coursac and S.L. Zeger: “Fine particulate air pollution and mortality in 20 U.S. cities, 1987–1994”, N. Engl. J. Med., Vol. 343, (2000), pp. 1742–1749. http://dx.doi.org/10.1056/NEJM200012143432401 [CrossRef]

  • [26] J.E. Vena: “Air pollution as a risk factor in lung cancer”, Am. J. Epidemiol., Vol. 116, (1982), pp. 42–56.

  • [27] Health Effects Institute: Revised analyses of time-series studies of air pollution and health, 46 Health Effects Institute, special report, Boston, MA, 2003.

  • [28] R.J. Delfino: “Epidemiologic evidence for asthma and exposure to air toxics: linkages between occupational, indoor, and community air pollution research”, Environ. Health Prespect., Vol. 110, (2002), pp. 573–589. http://dx.doi.org/10.1289/ehp.021100607 [CrossRef]

  • [29] W. Jedrychowski, R.M. Whyatt, D.E. Camman, U.V. Bawle, K. Peki, J.R. Spemgler, T.S. Dumyahn, A. Penar and F.P. Perera: “Effect of prenatal PAH exposure on birth outcomes and neurocognitive development in a cohort of newborns in Poland. Study design and preliminary ambient data”, Int. J. Occup. Med. Environ. Hlth., Vol. 16, (2003), pp. 21–29.

  • [30] P. Quanjer, G.J. Tammeling, G.J. Cotes, O.F. Pedersen, R. Peslin, J.C. Vernault: “Lung volumes and forced ventilatory flows”, Eur. Respir. J., Vol. 6, (1993), pp. 5–40. [CrossRef]

  • [31] British Thoracic Society, (Anonymous): “Guidelines for the measurement of respiratory function. Recommendations of the British Thoracic Society and the Association of Respiratory Technicians and Physiologists”, Respir. Med., Vol. 88(3), (1994), pp. 165–194. http://dx.doi.org/10.1016/S0954-6111(05)80346-4 [CrossRef]

  • [32] F.P. Perera, S.M. Illman, P.L. Kinney, R. Whyatt, E.A. Kelvin, P. Shepard, D. Evans, M. Fullilove, J. Ford, R.L. Miller, I.H. Meyer and V.A. Rauh: “The challenge of preventing environmentally related disease in young children: community-based research in New York City”, Environ. Health Perspect., Vol. 110, (2002), pp. 197–204. http://dx.doi.org/10.1289/ehp.02110197 [CrossRef]

  • [33] X. Xu, D.W. Dockery and I. Wang: “Effects of air pollution on adult pulmonary function”, Arch. Environ. Health, Vol. 46, (1991), pp. 198–206. http://dx.doi.org/10.1080/00039896.1991.9937448 [CrossRef]

  • [34] A.J. Ghio and R.B. Devlin: “Inflammatory lung injury after bronchial instillation of air pollution particles”, Am. J. Respir. Crit. Care Med., Vol. 164, (2001), pp. 704–708.

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