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Open Medicine

formerly Central European Journal of Medicine

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Hypovitaminosis D and cardiometabolic risk factors among non-obese youth

1Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Riyadh, Kingdom of Saudi Arabia

2Clinical Pharmacy Department, College of Pharmacy, King Saud University, 11451, Riyadh, Kingdom of Saudi Arabia

3Health Affairs for Riyadh Region, Ministry of Health, 11176, Riyadh, Kingdom of Saudi Arabia

4College of Applied Medical Sciences, King Saud University, 11451, Riyadh, Kingdom of Saudi Arabia

5King Abdulaziz Medical City, 11426, Riyadh, Kingdom of Saudi Arabia

6First Department of Pediatrics, Athens University Medical School, 11527, Athens, Greece

© 2010 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. (CC BY-NC-ND 3.0)

Citation Information: Open Medicine. Volume 5, Issue 6, Pages 752–757, ISSN (Online) 2391-5463, DOI: 10.2478/s11536-010-0045-2, October 2010

Publication History

Published Online:


Hypovitaminosis D and increased cardiometabolic risk have been well established in adults. This study aims to determine whether or not vitamin D also influences cardiometabolic risk in children and adolescents. To test this hypothesis, we recruited 186 boys (mean age 12.4 ± 3.7 years) and 114 girls (11.6 ± 3.7) in a cross-sectional observational study. Anthropometrics were obtained and morning fasting blood samples were collected. Serum glucose and lipid profile were determined using routine methods. Serum 25-hydroxyvitamin D was quantified using an enzyme-linked immunosorbent assay. In our population, approximately 10% of subjects had severe 25-hydroxyvitamin D deficiency (< 12.5 nmol/L), while 50% of the boys and 40% of the girls had mild vitamin D deficiency (12.5–24.9 nmol/L). Circulating 25-hydroxyvitamin D concentrations were inversely correlated with age, body mass index (BMI), blood pressure, waist and hip circumferences and serum triglyceride concentrations, and positively associated with HDL-cholesterol. Age and systolic blood pressure were significant predictors of 25-hydroxyvitamin D, explaining about 30% of the variance (p = 0.0005). In conclusion, significant associations between serum 25-hydroxyvitamin D and cardiometabolic parameters support promising cardioprotective benefits from vitamin D sufficiency at an early age. Follow-up with prospective clinical intervention studies are needed to validate this hypothesis.

Keywords: 25-Hydroxycholecalciferol; Hypovitaminosis D; Children

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