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Open Medicine

formerly Central European Journal of Medicine


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2391-5463
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Hypovitaminosis D and cardiometabolic risk factors among non-obese youth

1Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Riyadh, Kingdom of Saudi Arabia

2Clinical Pharmacy Department, College of Pharmacy, King Saud University, 11451, Riyadh, Kingdom of Saudi Arabia

3Health Affairs for Riyadh Region, Ministry of Health, 11176, Riyadh, Kingdom of Saudi Arabia

4College of Applied Medical Sciences, King Saud University, 11451, Riyadh, Kingdom of Saudi Arabia

5King Abdulaziz Medical City, 11426, Riyadh, Kingdom of Saudi Arabia

6First Department of Pediatrics, Athens University Medical School, 11527, Athens, Greece

© 2010 Versita Warsaw. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. (CC BY-NC-ND 3.0)

Citation Information: Open Medicine. Volume 5, Issue 6, Pages 752–757, ISSN (Online) 2391-5463, DOI: 10.2478/s11536-010-0045-2, October 2010

Publication History

Published Online:
2010-10-07

Abstract

Hypovitaminosis D and increased cardiometabolic risk have been well established in adults. This study aims to determine whether or not vitamin D also influences cardiometabolic risk in children and adolescents. To test this hypothesis, we recruited 186 boys (mean age 12.4 ± 3.7 years) and 114 girls (11.6 ± 3.7) in a cross-sectional observational study. Anthropometrics were obtained and morning fasting blood samples were collected. Serum glucose and lipid profile were determined using routine methods. Serum 25-hydroxyvitamin D was quantified using an enzyme-linked immunosorbent assay. In our population, approximately 10% of subjects had severe 25-hydroxyvitamin D deficiency (< 12.5 nmol/L), while 50% of the boys and 40% of the girls had mild vitamin D deficiency (12.5–24.9 nmol/L). Circulating 25-hydroxyvitamin D concentrations were inversely correlated with age, body mass index (BMI), blood pressure, waist and hip circumferences and serum triglyceride concentrations, and positively associated with HDL-cholesterol. Age and systolic blood pressure were significant predictors of 25-hydroxyvitamin D, explaining about 30% of the variance (p = 0.0005). In conclusion, significant associations between serum 25-hydroxyvitamin D and cardiometabolic parameters support promising cardioprotective benefits from vitamin D sufficiency at an early age. Follow-up with prospective clinical intervention studies are needed to validate this hypothesis.

Keywords: 25-Hydroxycholecalciferol; Hypovitaminosis D; Children

  • [1] Molina J.A., Heng B.H., Global trends in cardiology and cardiothoracic surgery — an opportunity or a threat?, Ann. Acad. Med. Singapore 2009, 38, 541–545

  • [2] Al-Nozha M.M., Abdullah M., Arafah M.R., Khalil M.Z., Khan N.B., Al-Mazrou Y.Y., et al., Hypertension in Saudi Arabia, Saudi Med. J. 2007, 28,77–84

  • [3] Al-Nozha M.M., Arafah M.R., Al-Maatouq M.A., Khalil M.Z., Khan N.B., Al-Marzouki K., et al., Hyperlipidemia in Saudi Arabia, Saudi Med. J. 2008, 29, 282–287

  • [4] Al-Nozha M., Al-Khadra A., Arafah M.R., Al-Maatouq M.A., Khalil M.Z., Khan N.B., et al., Metabolic syndrome in Saudi Arabia, Saudi Med. J. 2005, 26, 1918–1925

  • [5] El-Mouzan M.I., Al-Herbish A., Al-Salloum A.A., Al-Omar A.A., Qurachi M.M., Trends in the nutritional status of Saudi children, Saudi Med. J. 2008, 29, 884–887 [PubMed]

  • [6] Al-Hazzaa H.M., Prevalence of physical inactivity in Saudi Arabia: a brief review, East Mediterr. Health J. 2004, 10, 663–670

  • [7] Bawazeer N., Al-Daghri N., Valsamakis G., Al-Rubeaan K., Valsamakis G, Sabico S., et al., Sleep duration and quality associated with obesity among Arab children, Obesity 2009, 17, 2251–2253 http://dx.doi.org/10.1038/oby.2009.169 [CrossRef]

  • [8] Camhi S.M., Katzmarzyk P.T., Tracking of cardiometabolic risk factor clustering from childhood to adulthood, Int. J. Pediatr. Obes. 2009, 1–8 [CrossRef]

  • [9] Jiang S., Bao Y., Hou X., Fang O., Wang C., Pan J., et al., Serum C-reactive protein and risk of cardiovascular events in middle-aged and older Chinese population, Am. J. Cardiol. 2009, 103, 1727–1731 http://dx.doi.org/10.1016/j.amjcard.2009.02.028 [CrossRef]

  • [10] Zhou J., Austin R.C., Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms, Biofactors 2009, 35, 120–129 http://dx.doi.org/10.1002/biof.17 [Web of Science] [CrossRef]

  • [11] Mithal A., Wahl D.A., Bonjour J.P., Burckhardt P., Dawson-Hughes B., Eisman J.A., et al., Global vitamin D status and determinants of hypovitaminosis D, Osteoporosis Int. 2009, 20, 1807–1820 http://dx.doi.org/10.1007/s00198-009-0954-6 [Web of Science] [CrossRef]

  • [12] Judd S.E., Tangpricha V., Vitamin D deficiency and risk of cardiovascular disease, Am. J. Med. Sci. 2009, 338, 40–44 http://dx.doi.org/10.1097/MAJ.0b013e3181aaee91 [CrossRef]

  • [13] Forouhi N.G., Luan J., Cooper A., Boucher B.J., Wareham N.J., Baseline serum 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990–2000, Diabetes 2008, 57, 2619–2625 http://dx.doi.org/10.2337/db08-0593 [Web of Science]

  • [14] Moradzadeh K., Larijani B., Keshtar A., Hossein-Nezhad A., Rajabian R., Nabipour I., et al., Normative values of vitamin D among Iranian population: a population based study, Int. J. Osteoporosis Metabolic Disorders 2008, 1, 8–15 http://dx.doi.org/10.3923/ijom.2008.8.15 [CrossRef]

  • [15] Rovner A.J., O’Brien K.O., Hypovitaminosis D among healthy children in the United States, Arch. Pediatr. Adolesc. Med. 2008, 162, 513–519 http://dx.doi.org/10.1001/archpedi.162.6.513 [CrossRef]

  • [16] Bener A., Al-Ali M., Hoffman G.F., High prevalence of vitamin D deficiency in young children in a highly sunny humid country: a global health problem, Minerva Pediatr. 2009, 61, 15–22

  • [17] Sedrani S.H., Elidrissy A.W., El Arabi K.M., Sunlight and vitamin D status in normal Saudi subjects, Am. J. Clin. Nutr. 1983, 38, 129–132

  • [18] Al-Atawi M.S., Al-Alwan I.A., Al-Mutair A.N., Tanim H.M., Al-Jurayyan N.A., Epidemiology of nutritional rickets in children, Saudi J. Kidney Dis. Transpl. 2009, 20, 260–265

  • [19] McCarty M.F., Poor vitamin D status may contribute to high risk for insulin resistance, obesity and cardiovascular disease in Asian Indians, Med. Hypotheses 2009, 72, 647–651 http://dx.doi.org/10.1016/j.mehy.2008.12.031 [CrossRef] [Web of Science]

  • [20] Nemerovski C.W., Dorsch M.P., Simpson R.U., Bone H.G., Aaronson K.D., Bleske B.E., Vitamin D and cardiovascular disease, Pharmacotherapy 2009, 29, 691–708 http://dx.doi.org/10.1592/phco.29.6.691 [CrossRef] [Web of Science]

  • [21] Matias P.J., Ferreira C., Jorge C., Borges M., Aires I., Amaral T., 25-Hydroxyvitamin D3, arterial calcifications and cardiovascular risk markers in haemodialysis patients, Nephrol. Dial. Transplant 2009, 24, 611–618 http://dx.doi.org/10.1093/ndt/gfn502 [CrossRef]

  • [22] Alemzadeh R., Kichler J., Babar G., Calhoun M., Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity and season, Metabolism 2008, 57, 183–191 http://dx.doi.org/10.1016/j.metabol.2007.08.023 [CrossRef]

  • [23] Gannage-Yared M.H., Chedid R., Khalife S., Azzi E., Zoghbi F., Halaby G., Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population, Eur. J. Endocrinol. 2009, 160, 965–971 http://dx.doi.org/10.1530/EJE-08-0952 [CrossRef]

  • [24] Forman J.P., Giovannucci E., Holmes M.D., Bischoff-Ferrari H.A., Tworoger S.S., Willett W.C., et al., Plasma 25-hydroxyvitamin D levels and risk of incident hypertension, Hypertension 2007, 49, 1063–1069 http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.087288 [CrossRef]

  • [25] Hsia J., Heiss G., Ren H., Allison M., Dolan N.C., Greenland P., et al., Calcium/vitamin D supplementation and cardiovascular events, Circulation 2007, 115, 846–854 http://dx.doi.org/10.1161/CIRCULATIONAHA.106.673491 [CrossRef]

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