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Circulating oxidized low density lipoprotein and non-high density lipoprotein cholesterol concentrations in metabolic syndrome Egyptian women before and after specific nutritional therapy
1National Research Center - Food Science and Nutrition, Cairo, Egypt
2National Research Center - Food Science and Nutrition, Cairo, Egypt
3National Research Center - Food Science and Nutrition, Cairo, Egypt
4National Research Center - Food Science and Nutrition, Cairo, Egypt
5National Research Center - Food Science and Nutrition, Cairo, Egypt
6National Research Center - Food Science and Nutrition, Cairo, Egypt
This content is open access.
(CC BY-NC-ND 4.0)
Citation Information: Macedonian Journal of Medical Sciences. Volume 5, Issue 2, Pages 169–176, ISSN (Online) 1857-5773, ISSN (Print) 1857-5749, DOI: 10.3889/mjms.1857-5773.2012.0230, October 2012
- Published Online:
Aim: To investigate the relation between the metabolic syndrome (MetS), and oxidized low density lipoprotein (ox-LDL) and non-high density lipoprotein cholesterol (non-HDL-C), and to evaluate a dietary therapy composed of a balanced hypocaloric regimen plus a supplement prepared from whole wheat and tigernut flour (Cyperus Esculentus).
Material and Methods: Forty two obese Egyptian female volunteers (their mean age was 47.76± 0.90) were given a low caloric balanced diet (900-1000 kcal) for 4 weeks, and then the supplement was used to replace Baladi bread during the next four weeks. The metabolic syndrome was diagnosed according to the International Diabetes Federation criteria.
Results: The prevalence rate of MetS was found to be 76.2%.The metabolic syndrome was significantly associated with higher levels of total cholesterol (T.cholesterol), LDL-C, ox-LDL and non HDL-C. Significant and sustained reduction in the levels of fasting blood glucose and HbA1c, normalization of lipid profile, and decrease in the levels of ox-LDL were observed after the end of the two periods of the dietary therapy.
Conclusion: Metabolic syndrome is associated with higher levels of circulating ox-LDL and non-HDLC. The use of the dietary therapy composed of balanced hypocaloric regimen plus a supplement rich in antioxidants and anti-inflammatory components, reduced obesity and the risky biochemical markers of the MetS.