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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Weir, Ron / Stohner, Jürgen


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Species-selective determination of selenium compounds in biological materials (Technical Report)

R. Lobinski1 / J. S. Edmonds3 / K. T. Suzuki4 / P. C. Uden5

1CNRS UMR 5034, Hélioparc, 2, av. Pr. Angot, 64 000 Pau, France

2Warsaw University of Technology, Faculty of Chemistry, Department of Analytical Chemistry, ul. Noakowskiego 3, 00-664 Warszawa, Poland

3Department of Chemistry, De Montfort University, The Gateway, Leicester LE1 9BH, UK

4Faculty of Pharmaceutical Sciences, Chiba University, Inage, Chiba 263-8522, Japan

5Department of Chemistry, University of Massachusetts, Amherst, MA 01003-4510, USA

Project Year: 1991, Project Code: 523/6/91

Citation Information: Pure and Applied Chemistry. Volume 72, Issue 3, Pages 447–461, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: 10.1351/pac200072030447, January 2009

Publication History

Published Online:
2009-01-01

There is substantial evidence of the complexity of selenium speciation in living organisms and of the importance of the selective determination of the particular species of this element in order to understand its metabolism and biological significance in clinical chemistry, biology, toxicology, and nutrition. The state-of-the-art of analytical techniques available for this purpose is critically evaluated with particular emphasis on the element-selective detection and identification of the detected selenium compounds. Whereas there are a number of techniques available that are able to detect various selenium species in living organisms selectively, few techniques exist that are able to identify and to characterize the species detected.

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