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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Weir, Ron / Stohner, Jürgen

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Harmonized guidelines for single-laboratory validation of methods of analysis (IUPAC Technical Report)

Michael Thompson1 / Stephen L. R. Ellison2 / Roger Wood3

1Department of Chemistry, Birkbeck College (University of London), London WC1H 0PP, UK

2Laboratory of the Government Chemist, Queens Road, Teddington, Middlesex TW11 0LY, UK

3Food Standards Agency, c/o Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, UK

Project Year: 1997, Project Code: 501/8/97

Citation Information: Pure and Applied Chemistry. Volume 74, Issue 5, Pages 835–855, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: 10.1351/pac200274050835, January 2009

Publication History:
Published Online:
2009-01-01

Method validation is one of the measures universally recognized as a necessary part of a comprehensive system of quality assurance in analytical chemistry. In the past, ISO, IUPAC, and AOAC International have cooperated to produce agreed protocols or guidelines on the "Design, conduct and interpretation of method performance studies" [1], on the "Proficiency testing of (chemical) analytical laboratories" [2], on "Internal quality control in analytical chemistry laboratories" [3], and on "The use of recovery information in analytical measurement" [4]. The Working Group that produced these protocols/guidelines has now been mandated by IUPAC to prepare guidelines on the single-laboratory validation of methods of analysis. These guidelines provide minimum recommendations on procedures that should be employed to ensure adequate validation of analytical methods.

A draft of the guidelines has been discussed at an International Symposium on the Harmonization of Quality Assurance Systems in Chemical Laboratory, the proceedings from which have been published by the UK Royal Society of Chemistry.

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