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Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Weir, Ron / Stohner, Jürgen


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Cancer-chemopreventive effects of natural sweeteners and related compounds

Takao Konoshima1 / Midori Takasaki1

1Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan

Conference

International Symposium on Sweeteners, International Symposium on Sweeteners, SWEET, Sweeteners, 2nd, Hiroshima, Japan, 2001-11-13–2001-11-17

Citation Information: Pure and Applied Chemistry. Volume 74, Issue 7, Pages 1309–1316, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: 10.1351/pac200274071309, January 2009

Publication History

Published Online:
2009-01-01

To search for possible cancer-chemopreventive agents from natural resources, several natural sweeteners were screened by the in vitro assay indicated by the inhibitory effects of Epstein-Barr virus early antigen (EBV-EA) induction. Of active compounds that showed the remarkable inhibitory effects on the EBV-EA induction, stevioside, from the leaves of Stevia rebaudiana, and mogroside V, from the fruits of Momordica grosvenori, exhibited significant inhibitory effects on the two-stage mouse skin carcinogenesis in vivo induced by 7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA). The inhibitory effect of stevioside is stronger than that of glycyrrhizin, which had been known as an antitumor-promoter in chemical carcinogenesis. Furthermore, stevioside also inhibited mouse skin carcinogenesis initiated by peroxynitrite. These results suggest that stevioside and mogroside V might be valuable as chemopreventive agents for chemical carcinogenesis.

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