Deformed frogs and environmental retinoids : Pure and Applied Chemistry Jump to ContentJump to Main Navigation
Show Summary Details

Pure and Applied Chemistry

The Scientific Journal of IUPAC

Ed. by Burrows, Hugh / Weir, Ron / Stohner, Jürgen

IMPACT FACTOR increased in 2015: 2.615
5-year IMPACT FACTOR: 3.127
Rank 60 out of 163 in category Chemistry, Multidisciplinary in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 1.012
Source Normalized Impact per Paper (SNIP) 2014: 1.187
Impact per Publication (IPP) 2014: 2.785

249,00 € / $374.00 / £187.00*

See all formats and pricing


Select Volume and Issue
Loading journal volume and issue information...

Deformed frogs and environmental retinoids

David Gardiner1 / A. Ndayibagira1 / Felix Grün1 / Bruce Blumberg1

1Department of Developmental and Cell Biology, University of California, Irvine, CA 92697-2300, USA

Citation Information: Pure and Applied Chemistry. Volume 75, Issue 11-12, Pages 2263–2273, ISSN (Online) 1365-3075, ISSN (Print) 0033-4545, DOI: 10.1351/pac200375112263, January 2009

Publication History

Published Online:

Since the early 1990s, a substantial number of deformed frogs have been observed in North America, particularly in the upper Midwest and Canada. Attempts to understand the etiology of the deformed frog problem have met with limited success to date with nearly as many proposed explanations as research groups working on the problem. Models for the mechanism underlying the development of deformed frogs include parasite/predation, ultraviolet radiation, and chemical exposure. Each model has its strengths and weaknesses. Despite contentious debate among researchers, there is an overall consensus that the increasing prevalence of deformed frogs is the result of a water-borne contaminant that has recently appeared, or reached a critical concentration. Our detailed analysis of malformed frogs collected in Minnesota ponds and lakes suggested that limb patterning was being modified by the disruption of a retinoid-sensitive developmental signaling pathway. Accordingly, we focused in the identification and characterization of bioactive retinoids from lake water and showed that retinoid treatment of frog embryos at sensitive times of development could recapitulate the full spectrum of limb abnormalities observed in field specimens in the laboratory. These data have led to the conclusion that inappropriate modulation of retinoid signaling by environmental contaminants is the mechanism underlying the increased incidence of frog malformations.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Carla M. Teglia, Andrés M. Attademo, Paola M. Peltzer, Héctor C. Goicoechea, and Rafael C. Lajmanovich
Chemosphere, 2015, Volume 135, Page 24
Anna C. Molineaux, Jennifer A. Maier, Teresa Schecker, and Karen E. Sears
Birth Defects Research Part A: Clinical and Molecular Teratology, 2015, Volume 103, Number 3, Page 225
Norman Wagner, Wiebke Züghart, Valentin Mingo, and Stefan Lötters
Ecological Indicators, 2014, Volume 45, Page 394
Yujiang Wang, Jiangfei Chen, Changchun Du, Chunqi Li, Changjiang Huang, and Qiaoxiang Dong
Environmental Toxicology and Chemistry, 2014, Volume 33, Number 2, Page 431
Xiaoqin Wu, Jieqiong Jiang, and Jianying Hu
Environmental Science & Technology, 2013, Volume 47, Number 2, Page 807
Kavitha Chinathamby, Mayumi Allinson, Fujio Shiraishi, Andreas L. Lopata, Dayanthi Nugegoda, Vincent Pettigrove, and Graeme Allinson
Environmental Science and Pollution Research, 2013, Volume 20, Number 3, Page 1831
X. Wu, J. Jiang, Y. Wan, J. P. Giesy, and J. Hu
Proceedings of the National Academy of Sciences, 2012, Volume 109, Number 24, Page 9477
BEI Yongjian, MENG Shaoquan, LI Jianda, FENG Jianru, ZHOU Jianbing, and LI Guifen
Asian Herpetological Research, 2012, Volume 2, Number 4, Page 230
Kazuko Sawada, Daisuke Inoue, Yuichiro Wada, Kazunari Sei, Tsuyoshi Nakanishi, and Michihiko Ike
Environmental Toxicology and Chemistry, 2012, Volume 31, Number 2, Page 307
Dorina Szuroczki, Nicholas D. Vesprini, Tim R. B. Jones, Gaynor E. Spencer, and Robert L. Carlone
Parasitology Research, 2012, Volume 110, Number 1, Page 49
Jihène Ben Hassine, Vivian de Buffrénil, and Saïd Nouira
Journal of Herpetology, 2011, Volume 45, Number 4, Page 465
M. Allinson, F. Shiraishi, S. A. Salzman, and G. Allinson
Archives of Environmental Contamination and Toxicology, 2011, Volume 61, Number 4, Page 539
Monique Boily, Janik Thibodeau, and Marjolaine Bisson
Aquatic Toxicology, 2009, Volume 91, Number 2, Page 118
Reinier M. Mann, Ross V. Hyne, Catherine B. Choung, and Scott. P. Wilson
Environmental Pollution, 2009, Volume 157, Number 11, Page 2903
Jiří Novák, Martin Beníšek, and Klára Hilscherová
Environment International, 2008, Volume 34, Number 6, Page 898
Marcos Gridi-Papp, Cristina O. Gridi-Papp, and William I. Lutterschmidt
The Southwestern Naturalist, 2005, Volume 50, Number 4, Page 490
Xiaoqin Wu, Jianying Hu, Ai Jia, Hui Peng, Shimin Wu, and Zhaomin Dong
Environmental Toxicology and Chemistry, 2010, Volume 29, Number 11, Page 2491
Mari K. Reeves, Christine L. Dolph, Heidi Zimmer, Ronald S. Tjeerdema, and Kimberly A. Trust
Environmental Health Perspectives, 2008, Volume 116, Number 8, Page 1009
Katti Pancharatna, Manjunath Ghodageri, Prasad A. Deshpande, and Rutesh Javalkar
Journal of Applied Toxicology, 2010, Page n/a
Jonathan H. Barnard, Jonathan C. Collings, Andrew Whiting, Stefan A. Przyborski, and Todd B. Marder
Chemistry - A European Journal, 2009, Volume 15, Number 43, Page 11430
Daisuke Inoue, Koki Nakama, Hisae Matsui, Kazunari Sei, and Michihiko Ike
Bulletin of Environmental Contamination and Toxicology, 2009, Volume 82, Number 4, Page 399
Matthias W. Büttner, Christian Burschka, Jürgen O. Daiss, Diana Ivanova, Natacha Rochel, Sabrina Kammerer, Carole Peluso-Iltis, Audrey Bindler, Claudine Gaudon, Pierre Germain, Dino Moras, Hinrich Gronemeyer, and Reinhold Tacke
ChemBioChem, 2007, Volume 8, Number 14, Page 1688
D.-P. H?der, H. D. Kumar, R. C. Smith, and R. C. Worrest
Photochemical & Photobiological Sciences, 2007, Volume 6, Number 3, Page 267

Comments (0)

Please log in or register to comment.